Correction of Selenium Deficiency Has Effect on Thyroid Function

Correction of Selenium Deficiency Has Effect on Thyroid Function

Previous literature has found potential association between selenium deficiency and inactivated glutathione peroxidase and deiodinase, which may contribute to subsequent elevation of T4 and ratio of T4/T3. Conduction of a case-control study (ID: Liuyanping3) has been applied on Clinicaltrials.gov to further elucidate effect of selenium deficiency on thyroid function. Based on its data, the investigators will perform a randomized, placebo-controlled,single-blinded crossover study on 20 participants with selenium deficiency to verify health consequence of selenium.

Inclusion Criteria:

• Clinical diagnosis of selenium deficiency through serum selenium test in previous phase (ID: Liuyanping3) of the study
• Should have stable body weight in the latest 3 months;
• Should be not prescribed with thyroid hormone replacement therapy
• Should be without medical history of thyroid surgery or iodine radiotherapy
• Should have normal FT3, FT4 and TSH.

Exclusion Criteria:

• Clinical diagnosis of acute critical illness in the latest 1 year
• Have had weight fluctuation by more than 5%
• Eating disorders
• Neuropsychological disorders
• Allergy to corn or yeast