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Interventional crossover study on healthy volunteers aimed at evaluating the effect of the composition and timing of ingestion of different types of water on the urinary excretion of lithogenic substances; the study will also analyze the effect of potassium citrate on urine pH and lithogenic substances
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Phase 1 | Experimental | A=oligomineral water, B=oligomineral water |
|
| Phase 2 | Experimental | A=oligomineral water, B=bicarbonate-rich water |
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| Phase 3 | Experimental | A=bicarbonate-rich water, B=oligomineral water |
|
| Phase 4 | Experimental | A=bicarbonate-rich water, B=bicarbonate-rich water |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Water | Other | 1 liter of water in meals; 1 liter out of meals |
|
| Measure | Description | Time Frame |
|---|---|---|
| Urine composition | Assessed the same day of water ingestion |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Divisione di Nefrologia, Fondazione Policlinico Gemelli | Rome | 00168 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32514990 | Derived | Ferraro PM, Baccaro R, Baroni S, D'Alessandri L, Carpenito C, Di Daniele N, Urbani A, Gambaro G. Effect of water composition and timing of ingestion on urinary lithogenic profile in healthy volunteers: a randomized crossover trial. J Nephrol. 2021 Jun;34(3):875-881. doi: 10.1007/s40620-020-00769-2. Epub 2020 Jun 8. |
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| ID | Term |
|---|---|
| D014867 | Water |
| ID | Term |
|---|---|
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D007287 | Inorganic Chemicals |
| D000838 | Anions |
| D007477 |
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| Ions |
| D004573 | Electrolytes |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |