Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Beijing University of Chinese Medicine | OTHER |
| Chengdu University of Traditional Chinese Medicine | OTHER |
Not provided
Not provided
Not provided
Not provided
This ambispective cohort study aims to evaluate the effect of high altitudes environment on human's physiological and metabolic markers, specific markers of main human systems, and incidence rate and severity of chronic mountain sickness (CMS).
Qinghai-Tibet plateau is a high altitudes area with average 3,000-5,000 meters height in China. As the partial pressure of oxygen in inspired air falls with increasing terrestrial elevation above sea level, many physiological variables in human body could be affected by this hypobaric hypoxic environment. Up to date, there are no large scale clinical trials assessing these changes in chinese population. The study here would like to provide the newest medical information on the changes of physiological variables and correlation between specific risk factors in chinese adults living at high altitudes for work purpose.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Adults Living at Qinghai-Tibet Plateau for Work Purpose | Qinghai-Tibet Plateau is a high altitude area in which human would be exposed in chronic hypoxia environment. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Chronic hypoxic environment | Other | Chronic hypoxic environment. Since the partial pressure of oxygen in inspired air falls with increasing terrestrial elevation above sea level, many physiological variables in adults would be affected by the chronic hypoxia environment. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in weight from baseline at first year | Baseline and 1st year | |
| Change in blood pressure as measured by sphygmomanometer from baseline at first year | The blood pressure will be described in the format of diastolic pressure/systolic pressure, and the unit of measure is mmHg. | Baseline and 1st year |
| Change in serum lipid from baseline at first year | Baseline and 1st year | |
| Change in blood glucose from baseline at first year | Baseline and 1st year |
| Measure | Description | Time Frame |
|---|---|---|
| Change in weight from baseline at second year | Baseline and 2nd year | |
| Change in weight from baseline at third year | Baseline and 3rd year | |
| Change in blood pressure as measured by sphygmomanometer from baseline at second year |
| Measure | Description | Time Frame |
|---|---|---|
| Relationship between altitudes and pathological changes in human body under chronic hypoxic environment | Up to the 3rd year | |
| Relationship between age and pathological changes in human body under chronic hypoxic environment | Up to the 3rd year |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
The study population is adults who live at Qinghai-Tibet Plateau for Work Purpose.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tonghua Liu, Professor | Contact | +86-13801020306 | thliu@vip.163.com | |
| Yingchun He, Master | Contact | +86-13880930756 | 17190782@qq.com |
| Name | Affiliation | Role |
|---|---|---|
| Tonghua Liu, Professor | Tibetan Traditional Medical College | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tibetan Traditional Medical College | Recruiting | Lhasa | Tibet | China |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The blood pressure will be described in the format of diastolic pressure/systolic pressure, and the unit of measure is mmHg. |
| Baseline and 2nd year |
| Change in blood pressure as measured by sphygmomanometer from baseline at third year | The blood pressure will be described in the format of diastolic pressure/systolic pressure, and the unit of measure is mmHg. | Baseline and 3rd year |
| Change in serum lipid from baseline at second year | Baseline and 2nd year |
| Change in serum lipid from baseline at third year | Baseline and 3rd year |
| Change in blood glucose from baseline at second year | Baseline and 2nd year |
| Change in blood glucose from baseline at third year | Baseline and 3rd year |
| Pathological changes from baseline at first year in human body systems | Baseline and 1st year |
| Pathological changes from baseline at second year in human body systems | Baseline and 2nd year |
| Pathological changes from baseline at third year in human body systems | Baseline and 3rd year |
| The incidence rate and severity of chronic mountain sickness (CMS) | The diagnosis and severity of CMS is identified and assessed using "The Qinghai Chronic Mountain Sickness Score". The score ranges from 0 to 27, and a higher value means a worse outcome. | The 2nd year |
| The incidence rate and severity of chronic mountain sickness (CMS) | The diagnosis and severity of CMS is identified and assessed using "The Qinghai Chronic Mountain Sickness Score". The score ranges from 0 to 27, and a higher value means a worse outcome. | The 3rd year |
| Relationship between gender and pathological changes in human body under chronic hypoxic environment | Up to the 3rd year |