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Evaluation of resveratrol treatment oh ovarian hyperstimulation syndrome in egg donors
Randomized clinical trial to evaluate the role of resveratrol in preventing ovarian hyperstimulation syndrome by reducing VGEF expression and estradiol production, imporving hemoconcentration and symptomathology of this condition
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Resveratrol | Experimental | Resveratrol will be administered orally at the dose of 2 g/day for 9 days, starting on the day of ovulation triggering. |
|
| Control | Placebo Comparator | Placebo treatment will be administered for 9 days, starting on the day of ovulation triggering. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resveratrol | Drug | Resveratrol treatment (2 g/day) will be administered for 9 days, starting from oocyte maturation day. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Serum VEGF levels | Serum determination of VEGF levels | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Hemoconcentration | Volume of red blood cells measured in percentage | 1 day |
| Serum estradiol levels | Serum determination of estradiol levels asessed in picograms per mililiter |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ivi Madrid | Madrid | 28023 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22719052 | Background | Ortega I, Villanueva JA, Wong DH, Cress AB, Sokalska A, Stanley SD, Duleba AJ. Resveratrol reduces steroidogenesis in rat ovarian theca-interstitial cells: the role of inhibition of Akt/PKB signaling pathway. Endocrinology. 2012 Aug;153(8):4019-29. doi: 10.1210/en.2012-1385. Epub 2012 Jun 19. | |
| 22959450 | Background |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D000077185 | Resveratrol |
| ID | Term |
|---|---|
| D000081225 | Stilbestrols |
| D013267 | Stilbenes |
| D001597 | Benzylidene Compounds |
| D001555 | Benzene Derivatives |
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| Placebo | Drug | Placebo treatment (2 g/day) will be administered for 9 days, starting from oocyte maturation day. |
|
| 1 day |
| Ascitis | Volume of liquid in Douglas pouch asessed in mililiters | 1 day |
| Ortega I, Wong DH, Villanueva JA, Cress AB, Sokalska A, Stanley SD, Duleba AJ. Effects of resveratrol on growth and function of rat ovarian granulosa cells. Fertil Steril. 2012 Dec;98(6):1563-73. doi: 10.1016/j.fertnstert.2012.08.004. Epub 2012 Sep 6. |
| 20140899 | Background | Basini G, Tringali C, Baioni L, Bussolati S, Spatafora C, Grasselli F. Biological effects on granulosa cells of hydroxylated and methylated resveratrol analogues. Mol Nutr Food Res. 2010 Jul;54 Suppl 2:S236-43. doi: 10.1002/mnfr.200900320. |
| D006841 |
| Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D059808 | Polyphenols |
| D010636 | Phenols |