The Therapeutic Time Window of Mannitol During Craniotomy for Optimal Brain Relaxation in Patients With Supratentorial Tumours

Brain Relaxation Facilitated by Mannitol in Craniotomy: Insight Into the Optimized Operation Window

Although mannitol is used for brain relaxation during neurosurgery and in the treatment of raised intracranial pressure; there is not a consensus on its safe, effective dose and the duration of its administration. This study aimed to compare the effects of the mannitol in different use times, on the brain relaxation, electrolyte, lactate levels of the blood, peroperative fluid balance and the volume of the urine in supratentorial mass resection surgeries.

Inclusion Criteria:

• Intracranial shift >3mm
• Scheduled for supratentorial mass resection under elective conditions

Exclusion Criteria:

• Decompensated heart failure
• kidney insufficiency
• Diabetes insipidus,
• Electrolyte imbalance and
• Who are unconscious