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Although mannitol is used for brain relaxation during neurosurgery and in the treatment of raised intracranial pressure; there is not a consensus on its safe, effective dose and the duration of its administration. This study aimed to compare the effects of the mannitol in different use times, on the brain relaxation, electrolyte, lactate levels of the blood, peroperative fluid balance and the volume of the urine in supratentorial mass resection surgeries.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mannitol A | Experimental | in this group, Mannitol (1.0g/kg) is given just after the induction of general anesthesia |
|
| Mannitol B | Active Comparator | in this group, Mannitol (1.0g/kg) is given at the time of skin incision |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mannitol | Drug | This drug is in our routine use of neuroanesthesia, are given for facilitate brain relaxation |
|
| Measure | Description | Time Frame |
|---|---|---|
| brain relaxation score | difference in brain relaxation after drug administration The assessment was performed using a 4-point scale, 1 denoting bulging or the condition that additional methods for brain relaxation are immediately and always required in order to continue the surgical procedure because of brain swelling; 2, firm or the condition that additional methods for brain relaxation are occasionally required to continue the surgical procedure; 3, adequate; 4, perfectly relaxed. In all patients, the degree of brain relaxation was assessed at the time of dural opening and satisfactory brain relaxation was defined as a brain relaxation score of 3 or 4. All the Secondary Outcome Measures below are observed the safety for intraoperative brain debulking during elective supratentorial craniotomy | just before dural opening |
| Measure | Description | Time Frame |
|---|---|---|
| Blood sodium levels | change in 30 minute intervals in the first 2 hour after study drug administration | |
| Blood potassium levels | change in 30 minute intervals in the first 2 hour after study drug administration |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fudan University affiliated Huashan Hospital | Shanghai | Shanghai Municipality | 021 | China |
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| ID | Term |
|---|---|
| D015173 | Supratentorial Neoplasms |
| ID | Term |
|---|---|
| D001932 | Brain Neoplasms |
| D016543 | Central Nervous System Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
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| ID | Term |
|---|---|
| D008353 | Mannitol |
| ID | Term |
|---|---|
| D013402 | Sugar Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D002241 | Carbohydrates |
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| Blood chlorine levels | change in 30 minute intervals in the first 2 hour after study drug administration |
| Blood lactate levels | change in 30 minute intervals in the first 2 hour after study drug administration |
| Fluid balance during operation | change in 30 minute intervals in the first 2 hour after study drug administration |
| D009369 | Neoplasms |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |