Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study aims to assess the postprandial triglyceride response to the ingestion of a high-fat meal with co-ingestion of either galactose, or glucose.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Galactose | Experimental | Ingestion of 0.75 g/kg body mass of d-galactose monohydrate co-ingested with cream to provide 1 g/kg body mass of fat. |
|
| Glucose | Active Comparator | Ingestion of 0.75 g/kg body mass of dextrose monohydrate co-ingested with cream to provide 1 g/kg body mass of fat. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Galactose | Dietary Supplement | Co-ingestion of d-galactose with a high-fat meal |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Postprandial increase plasma triglyceride concentrations | Incremental area under the curve (iAUC) of plasma triglyceride concentrations | 5 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Postprandial plasma insulin concentrations | Incremental area under the curve (iAUC) of plasma insulin concentrations | 5 hours |
| Postprandial plasma glucose concentrations | Incremental area under the curve (iAUC) of plasma glucose concentrations |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department for Health, University of Bath | Bath | BA2 7AY | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32297937 | Derived | Watkins J, Simpson A, Betts JA, Thompson D, Holliday A, Deighton K, Gonzalez JT. Galactose Ingested with a High-Fat Beverage Increases Postprandial Lipemia Compared with Glucose but Not Fructose Ingestion in Healthy Men. J Nutr. 2020 Jul 1;150(7):1765-1772. doi: 10.1093/jn/nxaa105. |
Not provided
Not provided
Raw data will be made available online upon publication in a peer-reviewed journal.
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D006949 | Hyperlipidemias |
| ID | Term |
|---|---|
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D005690 | Galactose |
| D005947 | Glucose |
| ID | Term |
|---|---|
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |
Not provided
Not provided
Randomized, blinded crossover design.
Not provided
Not provided
Participants and the researchers performing biochemical analyses will be blinded to the intervention.
| Glucose |
| Dietary Supplement |
Co-ingestion of d-glucose with a high-fat meal |
|
| 5 hours |
| Postprandial plasma non-esterified fatty acid concentrations | Postprandial area under the curve of non-esterified fatty acid concentrations | 5 hours |
| Postprandial plasma lactate concentrations | Incremental area under the curve (iAUC) of plasma lactate concentrations | 5 hours |
| Postprandial subjective hunger ratings | Postprandial area under the curve of hunger ratings measured by visual analogue scales (0-100 mm) | 5 hours |
| Postprandial subjective fullness ratings | Postprandial area under the curve of fullness ratings measured by visual analogue scales (0-100 mm) | 5 hours |
| Postprandial subjective satisfaction ratings | Postprandial area under the curve of satisfaction ratings measured by visual analogue scales (0-100 mm) | 5 hours |
| Postprandial prospective food consumption ratings | Postprandial area under the curve of prospective food consumption ratings measured by visual analogue scales (0-100 mm) | 5 hours |
| Postprandial overall appetite ratings | Postprandial area under the curve of overall appetite ratings measured by visual analogue scales (0-100 mm) | 5 hours |