Low Intensity Exercise in Different Normobaric/Hypobaric Normoxic/Hypoxic Conditions.

The Effects of Low Intensity Exercise in Hypobaric vs. Normobaric Normoxic and Hypoxic Conditions on Baroreflex Sensitivity, Physiological Responses and Cerebral Functions in Pilots.

The main goal of this project is to investigate how low intensity cycling exercise (1.5W/kg, for 6 minutes) influences cerebral functions, such as: Cerebral blood flow, oxygenation, and other physiological variables in different normobaric and hypobaric hypoxic conditions.

Subjects will bike at 1W/kg for 6 minutes at different simulated altitude level in the hypobaric chamber at the FAI in Dübendorf. Concentration performance also will be measured to better understand how hypobaric and hypoxia conditions may affect physiological responses, cerebral and cognitive functions.

Inclusion Criteria:

• Study Indication
• Male and Female subjects from 18 years to 40 years of age
• Healthy volunteer
• Signed Informed Consent after being informed

Exclusion Criteria:

• Contraindications to the study intervention.
• Define drugs, treatments or interventions not allowed during the study or for specific periods of time prior to the intervention,
• Women who are pregnant or breast feeding,
• Intention to become pregnant during the course of the study,
• Known or suspected non-compliance, drug or alcohol abuse,
• Previous problem with hypoxia or altitude exposure,
• Known pathologies/diseases
• Relevant medical disorders
• Anemia or poor health
• History of flight sickness