The Effects of Tranexamic Acid on Blood Loss During Orthognathic Surgery

The Effects of Tranexamic Acid on Blood Loss During Orthognathic Surgery

This study seeks to answer the question: Does a single pre-operative dose of tranexamic acid have a statistically significant reduction in blood loss during orthognathic surgery?

If it does, this drug may begin to be used routinely during orthognathic surgery to reduce blood loss in our patients.

Inclusion Criteria:

• Patients undergoing either

  • Bilateral saggital split osteotomy (lower jaw surgery)
  • Lefort 1 osteotomy (upper jaw surgery)
  • Combination of BSSO and Lefort

• Patients between with ages of 16-65

• No cardiac comorbidities (hypertension, congenital heart malformation)

• No known coagulopathy

• No regular prescription medication altering normal blood coagulation (NSAIDs, other anticoagulants)

• ASA I and II patients

Exclusion Criteria:

• Patients younger than 16 and older than 40
• Patients with known coagulopathy
• Patients with cardiac comorbidities
• Patients with a family history of bleeding disorders
• Patients who have undergone previous orthognathic surgery
• ASA III patients or higher