The Effect of Local Infiltration of Tranexamic Acid on Postoperative Blood Loss in Orthognathic Surgery

The Effect of Local Infiltration of Tranexamic Acid on Postoperative Blood Loss in Orthognathic Surgery : A Randomized Controlled Trial

The effect of local infiltration of tranexamic acid in orthognathic surgery remains unclear. This study was conducted to evaluate the difference in postoperative blood loss, measured by surgical drain output, following orthognathic surgery. The investigation involved a within-subject comparison, where each side of the mandible received a different local anesthetic solution: one side was infiltrated with a mixture of lidocaine with adrenaline and tranexamic acid, while the other side received lidocaine with adrenaline and normal saline.

Inclusion Criteria:

• Patients aged 18-50 years
• undergoing orthognathic surgery (Bilateral sagittal split ramus osteotomies (BSSRO), with or without Le Fort I maxillary osteotomy)
• ASA physical status I-II

Exclusion Criteria:

• Genioplasty in the operation
• History of allergy to tranexamic acid
• History of thromboembolic disorders
• Use of medications affecting blood coagulation (antiplatelet or anticoagulants) within the past 2 weeks
• History of cerebrovascular disease
• Pregnant or breastfeeding women