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Insufficient recruitment
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The investigators aim to investigate the impact of thoracic radiation therapy on diffusion capacity of the lung (primary endpoint: diffusion capacity for nitric oxide, DLNO) and on exhaled nitric oxide.
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| Measure | Description | Time Frame |
|---|---|---|
| Change in diffusing capacity for nitric oxide (DLNO) | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT |
| Measure | Description | Time Frame |
|---|---|---|
| Diffusing capacity for carbon monoxide (DLCO) | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT |
| Transfer Coefficient for nitric oxide (DLNO/VA) |
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Inclusion Criteria:
Exclusion Criteria:
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The study population consists in patients with planned but not already commenced radiation therapy of the chest. Recruitment will be performed at the Radiation Oncology Clinic at University Hospital of Zurich.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Zurich | Zurich | 8091 | Switzerland |
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The course over time will be described.
| Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT |
| Transfer Coefficient for carbon monoxide (DLCO/VA) | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT |
| Ratio of DLNO and DLCO | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT |
| Alveolar-capillary membrane-diffusing capacity for carbon monoxide (DMCO) | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT |
| Pulmonary capillary blood volume (Vc) | This variable is a calculated variable. The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT |
| Alveolar Volume (VA) | This variable is a calculated variable. The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT |
| Fractional concentration of exhaled nitric oxide at a flow rate of 50mL/s (FENO50) | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT |
| Concentration of nitric oxide in the gas phase of the alveolar or acinar region (CANO) | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT |
| Tissue concentration of nitric oxide of the airway wall (CawNO) | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT |
| Airway compartment diffusing capacity of nitric oxide from the of of the airway wall to the gas stream (DawNO) | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT |
| Total flux of nitric oxide in the conducting airway compartment (JawNO) | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT |
| Forced expiratory volume in 1 second | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT |
| Forced vital capacity | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT |
| Forced expiratory flow between 25% and 75% of forced vital capacity | The course over time will be described. | Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT |