Self Transcranial Direct Current Stimulation for Pain in Older Adults With Knee Osteoarthritis

Self Transcranial Direct Current Stimulation for Pain in Older Adults With Knee Osteoarthritis (Self tDCS and Knee Pain)

The purpose of this study is to determine the feasibility and preliminary efficacy of two weeks of self Transcranial Direct Current Stimulation (tDCS) for pain in older patients with knee osteoarthritis (OA).

Inclusion Criteria:

• have self-reported unilateral or bilateral knee OA pain, according to American College of Rheumatology criteria
• have had knee OA pain in the past 3 months with an average of at least 3 on a 10 cm Visual Analog Scale (VAS) for pain
• can speak and read English
• have a device with internet access that can be used for secure video conferencing for real-time remote supervision
• have access to a distraction-free, well lit, clean environment with a safe area to store the device and device kit
• have no plan to change medication regimens for pain throughout the trial
• are able to travel to the coordinating center
• are willing and able to provide written informed consent prior to enrollment.

Exclusion Criteria:

• previous prosthetic knee replacement or non-arthroscopic surgery to the affected knee
• history of brain surgery, tumor, seizure, stroke, or intracranial metal implantation
• systemic rheumatic disorders, including rheumatoid arthritis, systemic lupus erythematosus, and fibromyalgia
• uncontrolled hypertension (i.e., systolic blood pressure/ diastolic blood pressure ≥ 150/95 mm Hg)
• heart failure
• history of acute myocardial infarction
• peripheral neuropathy
• alcohol/substance abuse
• cognitive impairment (i.e., Mini-Mental Status Exam score ≤ 23)
• pregnancy or lactation
• hospitalization within the preceding year for psychiatric illness