Genetic Analysis of Prostate Cancer to Identify Predictive Markers of Disease Relapse or Metastatic Evolution

Genomic Analysis in Localized or Locally Advanced Prostate Cancer. Identification of Biomarkers Predictive of Biochemical or Metastatic Recurrence

Developing a genetic study on localized or locally advanced prostate cancer. The aim of the study is to identify genomic alteration predictive of metastatic recurrence in the context of primary heterogeneity, by using the next generation sequencing (NGS) techniques.

Identifying such biomarkers may be useful to detect a higher relapse risk, and thus lower the mortality rate.

Inclusion Criteria:

• Patients managed by radical prostatectomy for prostate cancer between 2000 and 2016.
• Follow up > 6 years
• Negative pre surgical extension assessment
• Prognostic Grade Groups (OGG) III-IV-V
• Biochemical recurrence defined by 2 consecutive PSA rises ≥ 0,2 ng/mL
• Metastasis positive imaging

Exclusion Criteria:

• Neoadjuvant therapy
• Follow up < 6 years
• Prognostic Grade Groups (PGG) I-II
• Biochemical recurrence with metastasis negative imaging