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34 patients with Miller class III will be included in this study, where 17 participants will be treated with connective tissue graft with coronally advanced flap (control group) and 17 participants will be treated with a papillary extended connective tissue graft with coronally advanced flap (test group) and followed up for 6 months.
Each patient will be inspected to check if the patient fits for the eligibility criteria. If the patient meets the standards, phase I therapy for periodontal plastic procedures will be performed including thorough supragingival scaling and subgingival debridement. Preservation of appropriate plaque control (both mechanical and chemical) by the patient will be executed as well.
Surgical procedures:
It will be done by the principal investigator.
CTG harvesting:
A measurement of the approximate length and width of the graft required will be taken. A CTG will be harvested from the palate using single incision technique as described by Kumar et al. (2013) as follows:
The graft will be harvested from the palate between the distal aspect of the canine and the mid-palatal region of the first molar.
For the peCTG, the CTG will be furtherly prepared by creating the papillary extensions using a tissue punch, according to the number of teeth with gingival recession.
Surgical protocol:
The surgical area will be prepared and adequately anesthetized using 4% articaine hydrochloride 1/100 000 epinephrine by giving block and/or infiltration anesthesia. After attaining adequate anesthesia, at a point apical to the papilla tip, vertical incisions will be made lateral to the area of recession extending into alveolar mucosa. The alveolar mucosa between the two vertical incisions will then be undermined by sharp dissection with undermining going into the vestibule while remaining parallel with the surface. Then, a sulcular incision will be used to reflect the coronal portion of the flap by sharp dissection close to the periostium until reaching the split thickness incision
previously made in alveolar mucosa. A gingivoplasty of each papilla adjacent to the recession will then be performed. This excision will not reduce the height of the papilla, but is designed to create a bleeding surface which will serve as a bed for the connective tissue graft (Allen and Miller, 1989).
A triangular flap will be elevated by a sharp dissection with no. 15c scalpel blade to raise a combined full-partial thickness flap to the level of the MGJ.
In the test group (group A), peCTG will be placed over the recession defect leaving the coronal margin of the graft at the level of the CEJ, and the papillary extensions are inserted interdentally covering the de-epithelized papillae, while in the control group (group B), CTG will be also placed over the recession defect leaving the coronal margin of the graft at the level of the CEJ. In both groups, all graft material will be sutured to the periosteum using 6-0 resorbable suture. Finally the flaps will be positioned coronally to the CEJ without tension using 6-0 polyglycolic acid suture material. Hemostasis will be achieved by applying gentle finger pressure for 4 minutes.
Post-surgical protocol:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CTG+CAF | Active Comparator | The surgical procedure will include a connective tissue graft harvested from the palate and used under a coronally advanced flap |
|
| peCTG+CAF | Experimental | A papillary extended connective tissue graft reshaped after harvested from the palate will be used under a coronally advanced flap |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| peCTG+CAF | Procedure | A connective tissue graft will be reshaped to have extensions mimicking the papillae to augment the inter-dental papillae recessed |
|
| Measure | Description | Time Frame |
|---|---|---|
| Recession Depth in mm | The vertical amount of root exposed will be measured using a UNC-15 periodontal probe | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Recession Width in mm | The width of the exposed root will be measured using a UNC-15 periodontal probe | 6 months |
| Probing depth in mm | Measured from the gingival margin to the base of the sulcus will be measured using a UNC-15 periodontal probe |
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Inclusion Criteria:
Exclusion Criteria:
Handicapped and mentally retarded patients. Teeth with cervical restorations or abrasion. Taking medication known to affect periodontal healing. Previous periodontal surgery on the involved site.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Manar T Elzanaty, Master | Contact | +201001775660 | manar.elzanaty@dentistry.cu.edu.eg | |
| Noha A Ghallab, Doctorate | Contact | +201005263365 | noha.ghallab@dentistry.cu.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Manar T Elzanaty, Master | Cairo University | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22639845 | Background | Cairo F, Cortellini P, Tonetti M, Nieri M, Mervelt J, Cincinelli S, Pini-Prato G. Coronally advanced flap with and without connective tissue graft for the treatment of single maxillary gingival recession with loss of inter-dental attachment. A randomized controlled clinical trial. J Clin Periodontol. 2012 Aug;39(8):760-8. doi: 10.1111/j.1600-051X.2012.01903.x. Epub 2012 May 28. | |
| 25644302 |
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| ID | Term |
|---|---|
| D005889 | Gingival Recession |
| ID | Term |
|---|---|
| D005882 | Gingival Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| CTG+CAF | Procedure | A connective tissue graft harvested from the palate will be sutured to the gingival recession site and covered with a coronally advanced flap |
|
| 6 months |
| Gingival thickness in mm | the thickness of the gingival tissues will be measured by piercing the gingiva till touching bone with a #15 endodontic reamer under anethesia | 6 months |
| Width of keratinized gingiva in mm | from the gingival margin to the mucogingival junction will be measured using a UNC-15 periodontal probe | 6 months |
| Root coverage esthetic score (Cairo et al. 2009) | evaluation of the esthetic outcomes of root coverage procedures according to Cairo et al. 2009 Root Coverage Esthetic Score | 6 months |
| Patient satisfaction (Kim et al. 2014) | measuring the degree of satisfaction of the patients according to Kim et al. 2014 questionnaire | 6 months |
| Background |
| Chambrone L, Tatakis DN. Periodontal soft tissue root coverage procedures: a systematic review from the AAP Regeneration Workshop. J Periodontol. 2015 Feb;86(2 Suppl):S8-51. doi: 10.1902/jop.2015.130674. |
| 24174767 | Background | Kumar A, Sood V, Masamatti SS, Triveni MG, Mehta DS, Khatri M, Agarwal V. Modified single incision technique to harvest subepithelial connective tissue graft. J Indian Soc Periodontol. 2013 Sep;17(5):676-80. doi: 10.4103/0972-124X.119294. |
| 19335093 | Background | Cairo F, Rotundo R, Miller PD, Pini Prato GP. Root coverage esthetic score: a system to evaluate the esthetic outcome of the treatment of gingival recession through evaluation of clinical cases. J Periodontol. 2009 Apr;80(4):705-10. doi: 10.1902/jop.2009.080565. |
| D055093 |
| Periodontal Atrophy |