Hypofractionated PBI After BCS for Low-risk Breast Cancer Patients

Hypofractionated Partial Breast Irradiation After Breast-conserving Surgery for Low-risk Breast Cancer Patients

The study was designed to evaluate the feasibility and safety of hypofractionated partial breast irradiation after breast-conserving surgery for low-risk breast cancer patients.

A total dose of 40.05Gy in 15 fractions was delivered to the tumor bed for each eligible breast cancer patients. The endpoints including loco-regional recurrence, cosmetic outcomes, and toxicities, were evaluated after treatment.

Inclusion Criteria:

• Female
• Age≥ 50 years
• Treated with breast conversing surgery and sentinel lymph node biopsy or axillary lymph node dissection
• Negative surgical margins
• Pathologically confirmed invasive breast cancer
• A pathological T1N0M0 tumor -IHC: ER+/PR+/HER2-
• Tumor bed is labeled with Titanium clips
• Received adjuvant hormonal treatment
• No adjuvant chemotherapy
• ECOG:0-1
• Written informed consent.

Exclusion Criteria:

• Age<50 years
• KPS<70
• Treated with neoadjuvant chemotherapy
• Treated or being treated with chemotherapy
• With severe comorbidity
• Previous breast cancer or other malignant tumor history
• Previous radiotherapy for breast or thorax
• Medical contraindication for radiotherapy
• Pregnant or nursing