Hypofractionated Whole-breast Irradiation With Simultaneously Integrated Boost For Early-Stage Breast Cancer After Breast-conserving Surgery

Hypofractionated Whole-breast Irradiation With Simultaneously Integrated Boost For Early-Stage Breast Cancer After Breast-conserving Surgery

The study was designed to evaluate the feasibility and safety of hypofractionated whole-breast irradiation with simultaneously integrated boost for early-stage breast cancer after breast conserving surgery in Chinese population.

Inclusion Criteria:

• Female
• 18-60 years old
• Treated with breast conversing surgery and sentinel lymph node biopsy or axillary lymph node dissection
• Pathologically confirmed invasive breast cancer
• A pathological T1-2N0M0 tumor
• Tumor bed is labeled with Titanium clips
• Negative surgical margins
• Written informed consent.

Exclusion Criteria:

• KPS<70
• Treated with neoadjuvant chemotherapy
• Sentinel lymph nodes only containing isolated tumour cells (<0.2 mm)
• With severe comorbidity
• Previous breast cancer or other malignant tumor history
• Previous radiotherapy for breast or thorax
• Medical contraindication for radiotherapy
• Pregnant or nursing