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The goal of this trial is to examine long-term effects of laparoscopic gastric bypass (LRYGB) and sleeve gastrectomy (LSG) on bone mineral density, fracture risk, and body composition ≥ 5 years post-surgery.
Bariatric surgery shows impressive results in terms of weight loss and resolution of comorbidities. Still, there are questions as to the frequency of long-term adverse effects: data on alterations in bone health are missing,
The goal of this trial is to examine long-term effects of laparoscopic gastric bypass (LRYGB) and sleeve gastrectomy (LSG) on bone mineral density, fracture risk, and body composition ≥ 5 years post-surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Gastric Bypass | Active Comparator | Patients ≥ 5 years after laparoscopic gastric bypass receive DEXA (= Dual-energy x-ray absorptiometry) in order to measure bone mass density |
|
| Sleeve gastrectomy | Active Comparator | Patients ≥ 5 years after laparoscopic sleeve gastrectomy receive DEXA (= Dual-energy x-ray absorptiometry) in order to measure bone mass density |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DEXA (= Dual-energy x-ray absorptiometry) | Diagnostic Test | measurement of vertebral bone and hip bone mineral density |
|
| Measure | Description | Time Frame |
|---|---|---|
| Total hip T-Score measured with dual-energy x-ray absorptiometry | measured score will be compared to reference score for this age | 5-7 years after bariatric surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Total vertebral T-Score measured with dual-energy x-ray absorptiometry | measured score will be compared to reference score for this age | 5-7 years after bariatric surgery |
| fracture risk assessed by FRAX score |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bettina K Wölnerhanssen, MD | Clinical Research St. Claraspital Basel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St Claraspital | Basel | 4016 | Switzerland |
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| ID | Term |
|---|---|
| D009767 | Obesity, Morbid |
| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
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| ID | Term |
|---|---|
| D015502 | Absorptiometry, Photon |
| ID | Term |
|---|---|
| D011859 | Radiography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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measured score will be compared to reference score for this age
| 5-7 years after bariatric surgery |
| plasma concentration of C-terminal telopeptide (CTX) | measured plasma concentration will be compared to reference for this age | 5-7 years after bariatric surgery |
| plasma concentration of vitamin D3 | measured plasma concentration will be compared to reference for this age | 5-7 years after bariatric surgery |
| D009750 |
| Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003720 |
| Densitometry |
| D010783 | Photometry |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |