Pre-treatment With Methylene Blue Prevent Peri-operative Reduced Systemic Vascular Resistance

The Preventive Effects of Pre-treatment With Methylene Blue for Vascular Paralysis of the Patients With Obstructive Jaundice During Operation

To explore the effects of pre-treatment with methylene blue on reduced perioperative vascular resistance in patients with obstructive jaundice.

Hemodynamic characteristics of patients with obstructive jaundice are high cardiac output, low peripheral vascular resistance. The molecular basis for this feature is the increased production of NO. Methylene blue can increase peripheral resistance, the mechanism is: methylene blue is an oxidoreductase inhibitor, can inhibit the increased production of NO in the vascular endothelium, thereby increasing peripheral vascular resistance.

Inclusion Criteria:

1. Aged between 18-60 years;
2. American Society of Anesthesiologists（ASA） grade I~III;
3. TBIL>ULN and TBA>ULN; The patients with obstructive jaundice.

Exclusion Criteria:

1. Organs dysfunction(heart,lungs and etc);
2. Mental disorders;
3. in other clinical trial.