HBsAb Response After HBV Vaccination in Chronic Hepatitis B Patients Who Have Lost HBsAg

HBsAb Response After HBV Vaccination in Chronic Hepatitis B Patients Who Have Lost HBsAg

Chronic HBV infection is major problem in Asian countries. Years after chronic infection, in some cases serum HBsAg level declines to unmeasurable level. Some of patients develop anti-HBsAb but there is no standard treatment to accelerate HBsAg seroconversion.

There is a study to determine efficacy and safety of HBV vaccine in who is Chronic HBV infection and lost their HBsAg without seroconversion to anti-HBsAb.

Inclusion Criteria:

Chronic Hepatitis B infection group

• 18-80 year-old
• Compensated liver disease
• Chronic HBV infection with or without NUCs treatment
• History of HBsAg positive > 6 months
• HBsAg negative with qualitative Elecsys (Roche) twice at least 6 months apart
• HBsAb negative
• HBV DNA < 20 IU/mL

Healthy group

• Healthy person without history of HBV vaccination (HBsAg, anti-HBc and HBsAb negative)

Exclusion Criteria:

• History of previous HBV vaccination
• Anti-HCV and/or anti-HIV positive
• Decompensated cirrhosis
• History of previous malignancies
• History or currently receive immunotherapy, cytotoxic or immunosuppressive agents
• Patient with immunodeficiency disease
• Creatinine > 1.5 mg/dL
• Pregnancy or lactating woman
• Unable to consent