PET CT Re-Planning NSCLC (4DCT-PET)

Prospective Study of CT and PET Imaging During a Course of Radical Radiotherapy to Determine the Dosimetric Benefits of Re-Planning in Non-Small Cell Lung Cancer

This study will see whether the addition of more frequent planning CTs during the course of radiation, and of Positron Emission Tomography (PET), a diagnostic test similar to CT, prior to and during a course of radiation may provide information that could potentially be used during the treatment to improve the initial radiation plan.

Inclusion Criteria:

• Age equal to or more than 18 years old
• Patients with NSCLC consenting for radiotherapy to the primary tumor and / or mediastinal / hilar lymph nodes. Prescription doses should be 60Gy or higher.
• Chemo-RT patients of any stage of NSCLC
• Patients with a measurable tumor on CT scan.
• Patients who are able to lie supine for two consecutive 25 minutes sessions.

Exclusion Criteria:

• Trimodality patients who will have surgery within 2 months post RT
• Previous radiotherapy to intended treatment volumes.
• Patients with recurrent disease
• Active malignancy other than lung cancer
• Pregnancy
• Failure to provide written informed consent