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| ID | Type | Description | Link |
|---|---|---|---|
| CDR0000465501 |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
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RATIONALE: Imaging procedures, such as positron emission tomography (PET) scan and CT scan, may help doctors plan radiation therapy for patients with non-small cell lung cancer.
PURPOSE: This clinical trial is studying how well a combined PET scan and CT scan works compared to a CT scan alone in planning radiation therapy for patients with stage II or stage III non-small cell lung cancer.
OBJECTIVES:
Primary
Secondary
OUTLINE: This is a multicenter study. Patients are stratified according to neoadjuvant chemotherapy (yes vs no).
Patients undergo a combined positron emission tomography (PET)/CT scan. Patients also undergo a CT scan alone. A single three-dimensional conformal radiotherapy (3DCRT) plan is generated from the combined PET/CT scan results. A single 3DCRT plan using the planning target volume is derived from the CT scan only.
Patients are followed every 3 months for 1 year, every 6 months for 2 years, and then annually thereafter.
PROJECTED ACCRUAL: A total of 48 patients will be accrued for this study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Arm 1 | Experimental | Two radiation oncologists are randomly assigned to develop either a 3DCRT plan using CT only, or a 3DCRT plan using fused PET/CT |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| computed tomography | Procedure |
| ||
| positron emission tomography |
| Measure | Description | Time Frame |
|---|---|---|
| The impact of positron emission tomography (PET)/CT fusion planning on GTV (cm³) vs. planning with CT scan alone | Two treatment plans are centrally reviewed to determine the difference in gross tumor volume between the plans | |
| The impact of positron emission tomography (PET)/CT fusion planning on number of contoured lymph nodes vs. planning with CT scan alone | Two treatment plans are centrally reviewed to determine the difference in number of contoured lymph nodes between the plans | |
| The impact of positron emission tomography (PET)/CT fusion planning on location of involved lymph nodes vs planning with CT scan alone | Two treatment plans are centrally reviewed to determine the difference in location of involved lymph nodes between the plans | |
| The impact of positron emission tomography (PET)/CT fusion planning on lung V20 vs planning with CT scan alone | Two treatment plans are centrally reviewed to determine the difference in lung V20 between the plans | |
| The impact of positron emission tomography (PET)/CT fusion planning vs planning with CT scan alone on mean esophagus dose | Two treatment plans are centrally reviewed to determine the difference in mean esophagus dose between the plans |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of elective nodal failures as assessed by failure in previously uninvolved regional lymph nodes at 2 years | From registration to 2 years |
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DISEASE CHARACTERISTICS:
Histologically or cytologically confirmed non-small cell lung cancer (NSCLC)
Planning to undergo radiotherapy
Local or regional nodal recurrence after surgery allowed
No malignant pleural effusion
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
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| Name | Affiliation | Role |
|---|---|---|
| Jeffrey Bradley, MD | Mallinckrodt Institute of Radiology at Washington University Medical Center | Principal Investigator |
| Jacqueline Brunetti, MD | Sister Patricia Lynch Regional Cancer Center at Holy Name Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Siteman Cancer Center at Barnes-Jewish St. Peters Hospital - Saint Louis | St Louis | Missouri | 63110 | United States | ||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21075551 | Result | Bradley J, Bae K, Choi N, Forster K, Siegel BA, Brunetti J, Purdy J, Faria S, Vu T, Thorstad W, Choy H. A phase II comparative study of gross tumor volume definition with or without PET/CT fusion in dosimetric planning for non-small-cell lung cancer (NSCLC): primary analysis of Radiation Therapy Oncology Group (RTOG) 0515. Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):435-41.e1. doi: 10.1016/j.ijrobp.2010.09.033. Epub 2010 Nov 13. |
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| Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas |
| Dallas |
| Texas |
| 75390 |
| United States |
| University of Wisconsin Paul P. Carbone Comprehensive Cancer Center | Madison | Wisconsin | 53792-6164 | United States |
| McGill Cancer Centre at McGill University | Montreal | H2W 1S6 | Canada |
| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| D002289 | Carcinoma, Non-Small-Cell Lung |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |
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| ID | Term |
|---|---|
| D009682 | Magnetic Resonance Spectroscopy |
| ID | Term |
|---|---|
| D013057 | Spectrum Analysis |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
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