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Alpha-fetoprotein Levels on the Response to direct Antiviral Therapy in Patients with Chronic Hepatitis C
Impact of Serum Alpha-fetoprotein Levels on the Response to direct Antiviral Therapy in Egyptian Patients with Chronic Hepatitis C
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal Alfafetoprotein | Experimental | Sofosbuvir and Ledipasvir or sofosbuvir and daklatasuvir |
|
| Mild elevation of alfafetoprotein | Experimental | Sofosbuvir and Ledipasvir or sofosbuvir and daklatasuvir |
|
| High elevation of alfafetoprotein | Experimental | Sofosbuvir and Ledipasvir or sofosbuvir and daklatasuvir |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sofosbuvir and Ledipasvir or sofosbuvir and daklatasuvir | Drug | Response to DAAD's and developing HCC |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients with sustained virologic response | The total number of patients with SVR in each group | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sherief Abd-Elsalam, md | Contact | 00201095159522 | sheriefabdelsalam@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Rehab Badawi, MD | Tanta University | Principal Investigator |
| Mohamed Alboraie, MD | Al-Azhar University | Study Director |
| Sherief Abd-Elsalam, MD |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sherief Abd-Elsalam | Recruiting | Tanta | Egypt |
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| ID | Term |
|---|---|
| D006526 | Hepatitis C |
| ID | Term |
|---|---|
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D006525 | Hepatitis, Viral, Human |
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| ID | Term |
|---|---|
| D000069474 | Sofosbuvir |
| C586541 | ledipasvir |
| ID | Term |
|---|---|
| D014542 | Uridine Monophosphate |
| D014500 | Uracil Nucleotides |
| D011742 | Pyrimidine Nucleotides |
| D011743 | Pyrimidines |
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|
| Tanta University |
| Study Director |
| Mohamed el kassas, MD | Helwan University | Study Director |
| D014777 |
| Virus Diseases |
| D018178 | Flaviviridae Infections |
| D012327 | RNA Virus Infections |
| D006505 | Hepatitis |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D006573 |
| Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D009711 | Nucleotides |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides |
| D012265 | Ribonucleotides |