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To evaluate the benefit for statin use in prevention of of CI-AKI after computed tomography urogram (CTU).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Atorvastatin-Ascorbic acid | Active Comparator | atorvastatin (80-mg loading dose given a mean 24 hours before procedure with another 40-mg dose approximately 2 hours before the procedure and for 3 days) plus ascorbic acid 500mg |
|
| Placebo | Placebo Comparator | Placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Atorvastatin-Ascorbic acid | Drug | atorvastatin (80-mg loading dose given a mean 24 hours before procedure with another 40-mg dose approximately 2 hours before the procedure and for 3 days) plus ascorbic acid 500mg |
| Measure | Description | Time Frame |
|---|---|---|
| Contrast Induced-Acute Kidney Injury | Increase in serum creatinine ≥ 0.5 mg/dl or ≥ 25 % within 72 hours of contrast medium exposure. | 3 days |
| Measure | Description | Time Frame |
|---|---|---|
| long-term Renal function by estimated GFR | measured in ml/min/1.73m2 | 30 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yasser Othman, MD | Urology and nephrology center | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Urology and Nephrology Center | Al Mansurah | Aldakahlia | 35516 | Egypt |
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| Placebo | Drug | Placebo |
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