Effects Of Combination Therapy Of Statin And Ascorbic Acid For Prevention Of Contrast-Induced Nephropathy

Effects Of Combination Therapy Of Statin And Ascorbic Acid For Prevention Of Contrast-Induced Nephropathy. Randomised Controlled Study

To evaluate the benefit for statin use in prevention of of CI-AKI after computed tomography urogram (CTU).

Inclusion Criteria:

• Planned computed tomography urogram (CTU)
• Statin naive, or not on statin treatment for at least 14 day

Exclusion Criteria:

• History of liver disease or elevated serum transaminases
• History of rhabdomyolysis or elevated creatinine kinase
• History of iodinated CM use within 14 days before randomization
• History of N-acetylcysteine, metformin or nonsteroidal anti-inflammatory drugs use within 48 hours of the procedure.
• History of hypersensitivity reaction to contrast media
• Pregnancy or lactation
• Acute renal failure
• End-stage renal disease requiring dialysis
• Cardiogenic shock or pulmonary edema
• Multiple myeloma