Peri-operative Dexmedetomidine Infusion in Pre-eclamptic Patients

Peri-operative Dexmedetomidine Infusion in Mild Pre-eclamptic Patients Undergoing Elective Cesarean Section Under General Anesthesia

The purpose of this study is to investigate the effects of dexmedetomidine infusion on the stress response to intubation, postoperative analgesia, and renal functions (urinary output [UOP], creatinine and glomerular filtration rate [GFR]) in preeclamptic patient.

Inclusion Criteria:

• pregnant women
• have mild preeclampsia ( Pre-eclamptic patients will be defined as having hypertension [systolic blood pressure (SBP) ≥140 mmHg and/or diastolic blood pressure (DBP)≥90 mmHg] accompanied by proteinuria first detected after 20 weeks of gestation).
• Proteinuria is defined as at least 300 mg protein in 24 h urine collection [or ≥1+ dipstick (30 mg/dl) in a single urine sample] ).
• American Society of Anesthesiologists (ASA) physical status of II or III.
• age between 19 and 40 years

Exclusion Criteria:

• patient refusal to consent (obsolete).
• pre-existing neurological disease or psychic patients.
• history of cardiac and respiratory system failure.
• co-existing significant renal or liver disease.