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The aim of this study is compare the reversal of rocuronium induced neuromuscular blockade in morbidly obese patients using three doses of sugammadex; based on ideal body weight, adjusted body weight, and actual body weight.
The aim of this study is compare the reversal of rocuronium induced neuromuscular blockade in morbidly obese patients using three doses of sugammadex; based on ideal body weight, adjusted body weight, and actual body weight. Reversal Time: time from administration of Sugammadex to train of four (TOF) ratio ≥ 0.9 will be used as primary outcome.
Time need for extubation (time from administration of sugammadex to extubation), and duration of stay in post anesthesia care unit (PACU), will be used as secondary outcome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | Experimental | Sugammadex given in a dose of 2mg/kg based on ideal body weight |
|
| Group B | Experimental | Sugammadex given in a dose of 2mg/kg based on adjusted body weight |
|
| Group C | Experimental | Sugammadex given in a dose of 2mg/kg based on actual body weight |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sugammadex | Drug | sugammadex given based on 3 measurements of body weights |
|
| Measure | Description | Time Frame |
|---|---|---|
| Reversal Time | Reversal Time: time from administration of Sugammadex to train of four (TOF) ratio ≥ 0.9 will be used as primary outcome. | 5 minutes after sugammadex administration |
| Measure | Description | Time Frame |
|---|---|---|
| duration of stay in PACU | period of stay in the PACU | 60 minutes after admission to the PACU |
| Time need for Extubation | time from administration of sugammadex to extubation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Walid Nofal, MD | Anesthesiology department, Faculty of Medicine, Ain Shams University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine, Ain Shams University | Cairo | Egypt |
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| ID | Term |
|---|---|
| D000077122 | Sugammadex |
| ID | Term |
|---|---|
| D047408 | gamma-Cyclodextrins |
| D003505 | Cyclodextrins |
| D047028 | Macrocyclic Compounds |
| D011083 | Polycyclic Compounds |
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| 10 minutes after sugammadex administration |
| D003912 |
| Dextrins |
| D013213 | Starch |
| D005936 | Glucans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |