Efficacy of Low Dose Sugammadex in Reversal of NMB in Laparoscopic Barbaric Surgery

Comparison of Three Different Doses Sugammadex Based on Ideal Body Weight for Reversal of Moderate Rocuronium-induced Neuromuscular Blockade in Laparoscopic Bariatric Surgery.

the investigators aimed to compare the efficacy and safety of sugammadex at doses of 1.5, 2, and 4 mg/ kg for the reversal of moderate rocuronium-induced neuromuscular blockade in laparoscopic bariatric surgery.

Patients were randomly assigned using a randomization-computer program into three groups according to the dose of sugammadex administrated (according to the IBW after T2 of TOF):

Group I: patients were given 1.5 mg / kg. Group II: patients were given 2 mg / kg. Group III: patients were given 4 mg / kg.

Inclusion Criteria:

• morbidly obese patients of both sex (BMI > 40 kg.m-2)
• scheduled for elective laparoscopic bariatric surgery (gastric bypass or sleeve surgery) under general anesthesia using rocuronium for tracheal intubation and maintenance of NMB
• aged between 18 and 60 years and classified as ASA II - III

Exclusion Criteria:

• liver and renal dysfunction,
• disabling neuropsychiatric disorders,
• history of stroke, brain trauma in the last 12 months
• hypersensitivity to anesthetics, history of myocardial infarction, congestive heart failure
• difficult tracheal intubation, and known or suspected disorder affecting NMB.