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| ID | Type | Description | Link |
|---|---|---|---|
| 2017-A00852-51 | Other Identifier | ID-RCB number, ANSM |
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To explore predictors of major cardio-vascular events after cardiac surgery and trans-catheter valve implantation with a specific interest in studying mechanisms linking pre-operative leukocyte, fat and myocardial phenotypes with post-intervention outcomes.
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| Measure | Description | Time Frame |
|---|---|---|
| major cardio-vascular events after cardiac intervention (surgery or transcatheter valve implantation) | cardiovascular death, hospitalisation for heart failure, stroke, myocardial infarction, re-intervention | from the day of intervention to 10 years |
| Measure | Description | Time Frame |
|---|---|---|
| peri-operative myocardial injury | Area Under the Curve of blood troponin release during the 3 days following cardiac intervention | 3 days following intervention |
| post-operative myocardial infarction (type 5 myocardial infarction) |
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Inclusion Criteria:
Exclusion Criteria:
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All adult patients schedulled for cardiac surgery (coronary artery bypass graft surgery and/or valvular surgery) or transcatheter valve implantation and referred to the University Hospital of Lille with inclusion criteria and no exclusion criteria.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| David Montaigne, Prof. | Contact | 320445230 | +33 | david.montaigne@chru-lille.fr |
| Name | Affiliation | Role |
|---|---|---|
| David Montaigne, Prof. | University Hospital, Lille | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Cardiologie, CHU | Recruiting | Lille | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36990546 | Result | Ninni S, Dombrowicz D, Kuznetsova T, Vicario R, Gao V, Molendi-Coste O, Haas J, Woitrain E, Coisne A, Neele AE, Prange K, Willemsen L, Aghezzaf S, Fragkogianni S, Tazibet A, Pineau L, White JR, Eeckhoute J, Koussa M, Dubrulle H, Juthier F, Soquet J, Vincentelli A, Edme JL, de Winther M, Geissmann F, Staels B, Montaigne D. Hematopoietic Somatic Mosaicism Is Associated With an Increased Risk of Postoperative Atrial Fibrillation. J Am Coll Cardiol. 2023 Apr 4;81(13):1263-1278. doi: 10.1016/j.jacc.2023.01.036. | |
| 39206728 |
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| ID | Term |
|---|---|
| D006349 | Heart Valve Diseases |
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
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for all patients, blood samples with isolation of peripheral blood mononuclear cells, subcutaneous fat
for patients undergoing cardiac surgery right atrial and left ventricle myocardial samples; Epicardial and mediastinal fat
myocardial infarction during the peri-operative time
| 10 days following intervention |
| post-operative atrial fibrillation | atrial fibrillation onset during post-op hospitalisation | 10 days following intervention |
| major cardio-vascular events after cardiac intervention (surgery or transcatheter valve implantation) | cardiovascular death, hospitalisation for heart failure, stroke, myocardial infarction, re-intervention | from the day of intervention to 1 year |
| Derived |
| Ninni S, Vicario R, Coisne A, Woitrain E, Tazibet A, Stewart CM, Diaz LA Jr, White JR, Koussa M, Dubrulle H, Juthier F, Jungling M, Vincentelli A, Edme JL, Nattel S, de Winther M, Geissmann F, Dombrowicz D, Staels B, Montaigne D. Clonal Hematopoiesis Is Associated With Long-Term Adverse Outcomes Following Cardiac Surgery. J Am Heart Assoc. 2024 Sep 3;13(17):e034255. doi: 10.1161/JAHA.123.034255. Epub 2024 Aug 29. |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |