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| ID | Type | Description | Link |
|---|---|---|---|
| 5R01HL098601 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | NIH |
| Texas Heart Institute | OTHER |
| University of Texas Southwestern Medical Center | OTHER |
| Johns Hopkins University |
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This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure.
Patients undergoing heart surgery at Brigham and Women's Hospital and Texas Heart Institute are eligible to participate.
This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure. In addition, we also examine blood and urine biomarkers (proteins).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cardiac surgery | Adult patients undergoing cardiac surgery |
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| Measure | Description | Time Frame |
|---|---|---|
| Mortality (i.e. number of participants who are deceased during postoperative day 0 up to year 5) | Data will be collected from electronic medical records; data points to be collected for this measurement include serum creatinine. | Day of procedure to year 5 |
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| Measure | Description | Time Frame |
|---|---|---|
| Acute Kidney Injury using KDIGO criteria: albumin/creatinine ratio (>/= 300 mg/g) and eGRF (< 60 mL/min/1.73^2) | Data will be collected from electronic medical records; data points to be collected for this measurement include serum creatinine. | Day of procedure to post procedure day 7 |
| Presence of Arrhythmia (i.e. number of patients who develop an arrhythmia after their cardiac surgery) |
Inclusion Criteria:
Exclusion Criteria:
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Adult patients undergoing heart surgery
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| Name | Affiliation | Role |
|---|---|---|
| Jochen D Muehlschlegel, MD MMSc, MPH | Brigham and Women's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Brigham and Women's Hospital | Completed | Boston | Massachusetts | 02115 | United States | |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26009287 | Background | Sigurdsson MI, Muehlschlegel JD, Fox AA, Heydarpour M, Lichtner P, Meitinger T, Collard CD, Shernan SK, Body SC. Genetic Variants Associated With Atrial Fibrillation and PR Interval Following Cardiac Surgery. J Cardiothorac Vasc Anesth. 2015;29(3):605-10. doi: 10.1053/j.jvca.2014.10.028. Epub 2014 Nov 4. | |
| 25649697 | Background | Barnet CS, Liu X, Body SC, Collard CD, Shernan SK, Muehlschlegel JD, Jarolim P, Fox AA. Plasma corin decreases after coronary artery bypass graft surgery and is associated with postoperative heart failure: a pilot study. J Cardiothorac Vasc Anesth. 2015 Apr;29(2):374-81. doi: 10.1053/j.jvca.2014.11.001. Epub 2014 Nov 11. |
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| ID | Term |
|---|---|
| D020022 | Genetic Predisposition to Disease |
| D001281 | Atrial Fibrillation |
| D009203 | Myocardial Infarction |
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D004198 | Disease Susceptibility |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| OTHER |
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DNA, buffy coat, plasma, serum and urine
Data will be collected from electronic medical records; data points to be collected for this measurement include post-procedural EKG reports and progress notes. |
| Day of procedure to year 5 |
| Myocardial Infarction (i.e. number of participants who develop a MI during postoperative day 0 to year 5) | Data will be collected from electronic medical records; data points to be collected for this measurement include post-procedural EKG reports, cardiac enzyme values, progress notes, and cardiac catheterization reports. | Day of procedure to year 5 |
| Heart failure per NYHA class II, III, IV | This will be measured in accordance to New York Heart Association Guidelines. | Day of procedure to year 5 |
| Quality of Life Survey - The Kansas City Cardiomyopathy Questionnaire (KCCQShortForm) | A questionnaire to assess for heart failure | Administered once prior to the procedure and 1 month to 5 years after hospital discharge |
| Quality of Life Survey - The Seattle Angina Questionnaire (SAQShortForm) | A questionnaire to assess for angina | Administered once prior to the procedure and 1 month to 5 years after hospital discharge |
| Quality of Life Survey - 12-item short form health survey (SF12) | A questionnaire to assess for overall health | Administered once prior to the procedure and 1 month to 5 years after hospital discharge |
| UT Southwestern Medical Center |
| Recruiting |
| Dallas |
| Texas |
| 75390-9068 |
| United States |
|
| Department Texas Heart Institute at St. Luke's Episcopal Hospital | Completed | Houston | Texas | 77225 | United States |
| 21980348 | Background | Fox AA, Pretorius M, Liu KY, Collard CD, Perry TE, Shernan SK, De Jager PL, Hafler DA, Herman DS, DePalma SR, Roden DM, Muehlschlegel JD, Donahue BS, Darbar D, Seidman JG, Body SC, Seidman CE. Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery. PLoS One. 2011;6(9):e24593. doi: 10.1371/journal.pone.0024593. Epub 2011 Sep 30. |
| 21427536 | Background | Fox AA, Marcantonio ER, Collard CD, Thoma M, Perry TE, Shernan SK, Muehlschlegel JD, Body SC. Increased peak postoperative B-type natriuretic peptide predicts decreased longer-term physical function after primary coronary artery bypass graft surgery. Anesthesiology. 2011 Apr;114(4):807-16. doi: 10.1097/ALN.0b013e31820ef9c1. |
| 20837927 | Background | Muehlschlegel JD, Liu KY, Perry TE, Fox AA, Collard CD, Shernan SK, Body SC; CABG Genomics Investigators. Chromosome 9p21 variant predicts mortality after coronary artery bypass graft surgery. Circulation. 2010 Sep 14;122(11 Suppl):S60-5. doi: 10.1161/CIRCULATIONAHA.109.924233. |
| 20457766 | Background | Muehlschlegel JD, Perry TE, Liu KY, Fox AA, Collard CD, Shernan SK, Body SC. Heart-type fatty acid binding protein is an independent predictor of death and ventricular dysfunction after coronary artery bypass graft surgery. Anesth Analg. 2010 Nov;111(5):1101-9. doi: 10.1213/ANE.0b013e3181dd9516. Epub 2010 May 10. |
| 20435938 | Background | Perry TE, Muehlschlegel JD, Liu KY, Fox AA, Collard CD, Shernan SK, Body SC; CABG Genomics Investigators. Plasma neutrophil gelatinase-associated lipocalin and acute postoperative kidney injury in adult cardiac surgical patients. Anesth Analg. 2010 Jun 1;110(6):1541-7. doi: 10.1213/ANE.0b013e3181da938e. Epub 2010 Apr 30. |
| 20179497 | Background | Perry TE, Muehlschlegel JD, Liu KY, Fox AA, Collard CD, Body SC, Shernan SK; CABG Genomics Investigators. Preoperative C-reactive protein predicts long-term mortality and hospital length of stay after primary, nonemergent coronary artery bypass grafting. Anesthesiology. 2010 Mar;112(3):607-13. doi: 10.1097/ALN.0b013e3181cea3b5. |
| 19820236 | Background | Garvin S, Muehlschlegel JD, Perry TE, Chen J, Liu KY, Fox AA, Collard CD, Aranki SF, Shernan SK, Body SC. Postoperative activity, but not preoperative activity, of antithrombin is associated with major adverse cardiac events after coronary artery bypass graft surgery. Anesth Analg. 2010 Oct;111(4):862-9. doi: 10.1213/ANE.0b013e3181b7908c. Epub 2009 Oct 9. |
| 19426506 | Background | Perry TE, Muehlschlegel JD, Liu KY, Fox AA, Collard CD, Body SC, Shernan SK; CABG Genomics Investigators. C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery. BMC Med Genet. 2009 May 8;10:38. doi: 10.1186/1471-2350-10-38. |
| 19406870 | Background | Muehlschlegel JD, Perry TE, Liu KY, Nascimben L, Fox AA, Collard CD, Avery EG, Aranki SF, D'Ambra MN, Shernan SK, Body SC; CABG Genomics Investigators. Troponin is superior to electrocardiogram and creatinine kinase MB for predicting clinically significant myocardial injury after coronary artery bypass grafting. Eur Heart J. 2009 Jul;30(13):1574-83. doi: 10.1093/eurheartj/ehp134. Epub 2009 Apr 30. |
| 20031626 | Derived | Body SC, Collard CD, Shernan SK, Fox AA, Liu KY, Ritchie MD, Perry TE, Muehlschlegel JD, Aranki S, Donahue BS, Pretorius M, Estrada JC, Ellinor PT, Newton-Cheh C, Seidman CE, Seidman JG, Herman DS, Lichtner P, Meitinger T, Pfeufer A, Kaab S, Brown NJ, Roden DM, Darbar D. Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery. Circ Cardiovasc Genet. 2009 Oct;2(5):499-506. doi: 10.1161/CIRCGENETICS.109.849075. Epub 2009 Aug 2. |
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D017202 | Myocardial Ischemia |
| D014652 | Vascular Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D009336 | Necrosis |