Acute Neuroimmune Effects of Alcohol Using Free Water Imaging

Acute Neuroimmune Effects of Alcohol Using Free Water Imaging

This study examines the effects of moderate alcohol intake on the brain, the immune system, and cognition.

The study involves a within-subjects, pre/post design to assess the effects of a moderate dose of alcohol on immune biomarkers, neurobiological measures, and cognitive functioning. The study recruits healthy adults (ages 21-45) from the community to complete the experimental protocol. Participants complete magnetic resonance imaging scans, blood sample collection, and cognitive testing in the context of alcohol consumption.

Inclusion Criteria:

• Ages 21-45 years
• Able to speak and read English at least at 8th grade level
• Moderate self-reported alcohol use in the past year
• Body mass index in normal to overweight range
• Right-handed

Exclusion Criteria:

• History of heavy drinking
• Currently seeking alcohol or drug treatment
• Chronic disease requiring use of medication
• Recent antibiotic or probiotic use
• Chronic daily use of NSAIDs
• Chronic GI disorder
• Use of illicit drugs
• Major psychiatric disorder or suicidality
• Fainting, weakness, infection, excessive bruising, or distress resulting from standard blood draw
• Safety contraindication for MRI scan
• Inability to abstain from use of tobacco products prior to or during study
• Inability to abstain from use of cannabis prior to or during study
• Pregnant, nursing, or may become pregnant