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| ID | Type | Description | Link |
|---|---|---|---|
| G1002151 | Other Grant/Funding Number | MRC |
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To compare the urinary metabolomes on individuals undergone three different healthy diets--a carbohydrate-rich diet, a protein-rich diet, or a diet rich in unsaturated fat.
BACKGROUND:
This study based on the OmniHeart dietary intervention study, a randomized, three period cross-over feeding study that compared the effects on blood pressure and plasma lipids of three DASH-like diets: a carbohydrate-rich (CARB) diet pattern, a rich in protein (PROT) and a rich in unsaturated (MUFA) fat, predominantly monounsaturated fat diet (see full details of OmniHeart dietary intervention https://clinicaltrials.gov/ct2/show/record/NCT00051350).
This metabonomic study aims to evaluate the feasibility of identifying individuals showing variation in clinical response to three different healthy diets, with the purpose of reducing cardiovascular disease (CVD) risk, using proton nuclear magnetic resonance (NMR) based metabolic phenotyping approach.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Baseline | Placebo Comparator | Baseline corresponds to typical American diet |
|
| PROT rich diet | Active Comparator | Protein rich diet for 6 weeks |
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| MUFA rich diet | Active Comparator | MUFA rich diet for 6 weeks |
|
| CARB rich diet | Active Comparator | CARB rich diet for 6 weeks |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CARB rich diet | Other | Consumed CARB rich diet for 6 weeks with a washout period of at least 2 weeks before the next intervention |
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| Measure | Description | Time Frame |
|---|---|---|
| Systolic blood pressure (SBP) | SBP reduction in mmHg | post 6 weeks intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Diastolic blood pressure (DBP) | DBP reduction in mmHg | post 6 weeks intervention |
| low density lipoprotein cholesterol (LDL) | LDL reduction in mg/dl |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29506183 | Derived | Loo RL, Zou X, Appel LJ, Nicholson JK, Holmes E. Characterization of metabolic responses to healthy diets and association with blood pressure: application to the Optimal Macronutrient Intake Trial for Heart Health (OmniHeart), a randomized controlled study. Am J Clin Nutr. 2018 Mar 1;107(3):323-334. doi: 10.1093/ajcn/nqx072. |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| MUFA rich diet | Other | Consumed MUFA rich diet for 6 weeks with a washout period of at least 2 weeks before the next intervention |
|
| PROT rich diet | Other | Consumed PROT rich diet for 6 weeks with a washout period of at least 2 weeks before the next intervention |
|
| post 6 weeks intervention |
| high density lipoprotein cholesterol (HDL) | HDL reduction in mg/dl | post 6 weeks intervention |
| triglycerides (TG) | TG reduction in mg/dl | post 6 weeks intervention |
| total cholesterol | reduction in mg/dl | post 6 weeks intervention |