Aim-to conduct a randomized clinical intervention study to compare three diets (low-fat, low-carbohydrate and Mediterranean diet) for weight loss

Aim-to conduct a randomized clinical intervention study to compare three diets (low-fat, low-carbohydrate and Mediterranean diet) for weight loss

Inclusion Criteria:

• BMI>27
• age>40
• History of CHD or diabetes in any age or BMI level

Exclusion Criteria:

• Pregnant or lactating women.
• Active drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements.
• Serum creatinine > 3 mg/dl.
• Liver dysfunction ( ³ 2 fold level of ALT and AST enzymes).
• Participation in another trial in which active intervention is being received.
• Any intestinal problem that would prevent the patient from eating one of the test diets (for example, gastric stapling that might prevent consumption of vegetables).