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to study the effect of oral gabapentin (5 mg/kg) on emergence agitation after desflurane anesthesia in pediatrics undergoing starbismus surgery
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | Placebo Comparator | patients received strawberry juice 5 ml volume, one hour before induction. |
|
| Gabapentin group | Active Comparator | patients received gabapentin (Neurontin oral solution 250 mg/ml, Pfizer, USA) 5 mg/kg mixed with strawberry juice to constitute 5 ml volume, one hour before induction. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Strawberry juice as (placebo) | Drug | Patients received strawberry juice 5 ml volume, one hour before induction. |
|
| Measure | Description | Time Frame |
|---|---|---|
| emergence agitation incidence and scores | agitation measured by emergence agitation scale: [1= Obtunded with no response to stimuli; 2= Asleep, but responsive to movement and stimuli; 3= Awake and appropriately responsive; and 4= Crying and difficult to console; 5= Wild thrashing behaviour that requires restraint]. A score 4 or 5 was considered as agitation and was treated by IV meperidine 0.5 -1 mg/kg increments. | through study completion, an average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| duration of emergence | The time from the discontinuation of anesthesia till the time of spontaneous eye opening or to verbal command | through study completion, an average of 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ahmed A. BAdawy, MD | Contact | +96597700293 | dr.ahmedbadawy545@gmail.com | |
| Nicolas Abou Chaar, MsSc | Contact | +96597714558 | nicolas.abouchaar@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kuwait Specialized Eye Center | Recruiting | Kuwait City | 113111 | Kuwait |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29925328 | Derived | Badawy AA, Kasem SA, Rashwan D, Al Menesy T, Adel G, Mokhtar AM, Badawy YA. The role of Gabapentin oral solution in decreasing desflurane associated emergence agitation and delirium in children after stabismus surgery, a prospective randomized double-blind study. BMC Anesthesiol. 2018 Jun 20;18(1):73. doi: 10.1186/s12871-018-0533-5. |
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| ID | Term |
|---|---|
| D000077206 | Gabapentin |
| ID | Term |
|---|---|
| D000588 | Amines |
| D009930 | Organic Chemicals |
| D005680 | gamma-Aminobutyric Acid |
| D000613 | Aminobutyrates |
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| Gabapentin Oral Solution [Neurontin] | Drug | Patients received gabapentin (Neurontin oral solution 250 mg/ml, Pfizer, USA) 5 mg/kg mixed with strawberry juice to constitute 5 ml volume, one hour before induction. |
|
|
| D002087 |
| Butyrates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D003509 | Cyclohexanecarboxylic Acids |
| D000146 | Acids, Carbocyclic |
| D003510 | Cyclohexanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |