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Unexplained infertility is clinically diagnosed when there are no apparent or clear factors causing infertility on regular infertility assessment tools . Failure of implantation is a possible factor causing unexplained infertility . Implantation is the main rate limiting step in IVF outcome. Implantation is described at cellular and molecular level by adhesion or fixation of good quality embryo to receptive endometrium within a critical period of time which is called the window of implantation .
Testing the effect of Physical manipulation of the endometrium on the quality of the endometrium prior to ICSI cycle and if it increases the success rate
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| manipulation of endometrium | Experimental | The arm is physical manipulation to the endometrium prior to ICSI By one of these interventions )Hydrotubation , Sonohysterography or endometrial scratching |
|
| no manipulation to endometrium in ICSI | Placebo Comparator | This is the control group , with no manipulation to endometrium prior to ICSI No intervention to this group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hydrotubation | Device |
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| Measure | Description | Time Frame |
|---|---|---|
| The number of participants who achieved clinical pregnancy | Describes how many participant will continue pregnancy after positive pregnancy test | 6 weeks after embryo transfer |
| Measure | Description | Time Frame |
|---|---|---|
| The number of participants who achieved ongoing pregnancy and live birth | Describes who many participant will continue pregnancy till he had birth and a live birth | 9 months after embryo transfer |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mahmoud Alalfy, master | Algazeerah hospital -Location (Giza -Egypt ) | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Algazeerah | Giza | Egypt |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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640 were enrolled but 608 were analyzed
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