Physical Endometrial Manipulation and Its Effect on ICSI

Physical Endometrial Manipulation and Its Effect on Success Rate in Patients With Previous ICSI Failure

Unexplained infertility is clinically diagnosed when there are no apparent or clear factors causing infertility on regular infertility assessment tools . Failure of implantation is a possible factor causing unexplained infertility . Implantation is the main rate limiting step in IVF outcome. Implantation is described at cellular and molecular level by adhesion or fixation of good quality embryo to receptive endometrium within a critical period of time which is called the window of implantation .

Testing the effect of Physical manipulation of the endometrium on the quality of the endometrium prior to ICSI cycle and if it increases the success rate

Inclusion Criteria:

• Infertile female age 20-35 years
• Previous Failed one ICSI trial
• normal basal hormonal profile [FSH, LH] 3-10 mIU/ml and 1.8-8.5 mIU/ml respectively, --normal endometrial cavity
• patent tubes
• normal Husband semen analysis

Exclusion Criteria:

• Ovarian factor of infertility
• Tubal factor of infertility
• Endometrial factor of infertility
• Male factor of infertility