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Patients with lung nodules/mass found by CT (computed tomography) or PET (positron emission tomography) who agree to receive lung resection are arranged to test the dielectric property before receiving the frozen pathological examination. And the final pathological results are recognized as the standard diagnosis. Then the sensitivity and specificity of the dielectric property test will be evaluated comparing with the frozen pathological examination.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| dielectric property test | Experimental | The patient with lung nodules/mass is firstly arranged to be tested for dielectric property after the nodules/mass resection and cutting open. |
|
| frozen pathological examination | Placebo Comparator | The resected lung nodules/mass will be sent for frozen pathological examination after dielectric property test. |
|
| final pathological examination | Other | The resected lung nodules/mass will undergo the final pathological examination for final diagnosis after dielectric property test and frozen pathological examination. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| dielectric property test | Diagnostic Test | Test the dielectric property of resected lung nodules/mass through a touching probe after the lung tissue with nodules/mass has been resected and cut open, which usually takes only 1-5 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| sensitivity of dielectric property test in diagnosing lung nodules/masses | true positive rate in diagnosing lung nodules/masses | 3-5 years |
| specificity of dielectric property test in diagnosing lung nodules/masses | true negative rate in diagnosing lung nodules/masses | 3-5 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Di Lu, MD,PhD | Contact | 86+13268379321 | david_lu1989@163.com | |
| Siyang Feng, MD | Contact | 86+13570930671 | fengsy89@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Di Lu, MD,PhD | Nanfang Hospital, Southern Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nanfang Hospital, Southern Medical University | Recruiting | Guandong | Guangdong | 510515 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 8938024 | Background | Gabriel C, Gabriel S, Corthout E. The dielectric properties of biological tissues: I. Literature survey. Phys Med Biol. 1996 Nov;41(11):2231-49. doi: 10.1088/0031-9155/41/11/001. | |
| 8938025 | Background | Gabriel S, Lau RW, Gabriel C. The dielectric properties of biological tissues: II. Measurements in the frequency range 10 Hz to 20 GHz. Phys Med Biol. 1996 Nov;41(11):2251-69. doi: 10.1088/0031-9155/41/11/002. |
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The results of dielectric property test, frozen pathological test and final pathological examination of each individual participant.
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self-control method
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| frozen pathological examination | Diagnostic Test | And after the dielectric property test, the lung tissue will be sent for frozen pathological examination. |
|
| final pathological examination | Diagnostic Test | All of the lung nodules/mass will be diagnosed by final pathological examination and recognized as the final diagnosis after surgery. |
|
| 8938026 | Background | Gabriel S, Lau RW, Gabriel C. The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues. Phys Med Biol. 1996 Nov;41(11):2271-93. doi: 10.1088/0031-9155/41/11/003. |
| 8058021 | Background | Joines WT, Zhang Y, Li C, Jirtle RL. The measured electrical properties of normal and malignant human tissues from 50 to 900 MHz. Med Phys. 1994 Apr;21(4):547-50. doi: 10.1118/1.597312. |
| 1479201 | Background | Lu Y, Li B, Xu J, Yu J. Dielectric properties of human glioma and surrounding tissue. Int J Hyperthermia. 1992 Nov-Dec;8(6):755-60. doi: 10.3109/02656739209005023. |
| 2834285 | Background | Surowiec AJ, Stuchly SS, Barr JB, Swarup A. Dielectric properties of breast carcinoma and the surrounding tissues. IEEE Trans Biomed Eng. 1988 Apr;35(4):257-63. doi: 10.1109/10.1374. No abstract available. |
| 24417349 | Background | Fu F, Xin SX, Chen W. Temperature- and frequency-dependent dielectric properties of biological tissues within the temperature and frequency ranges typically used for magnetic resonance imaging-guided focused ultrasound surgery. Int J Hyperthermia. 2014 Feb;30(1):56-65. doi: 10.3109/02656736.2013.868534. Epub 2014 Jan 13. |