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Physical activity is considered a therapeutic strategy in its own right in a vast majority of disabling chronic disorders. It leads to an increase in physical and probably cognitive capacity, thanks to its effects on both metabolism (muscle hypertrophy, improvement in oxidative metabolism) and the nervous system (neuroplasticity). Nonetheless, even though there is a consensus on the positive effects of physical exercise (PE) on cerebral plasticity, the physiological mechanisms by which PE affects neuroplasticity, in particular depending on the mode of muscle contraction, are still hypothetical. Moreover, several recent studies have shown that mental learning (ML) by motor imagery improves motor performance, thus making it of interest in a context of rehabilitation, in particular in situations where PE is transient of definitively impossible. Yet, the mechanisms and brain structures involved in motor learning by ML have not been established so far. Finally, on the basis of clinical observations concerning the key role of sensory input in motor function, the hypothesis that increased demand on this input by electrical stimulation (ES) as a means to improve motor function has been proposed. However, the mechanisms by which this type of stimulation could induce neuroplasticity is still to be elucidated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| healthy volunteers | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| physical training | Other | workout on treadmill requiring the muscles of the lower limbs mostly in concentric (ascent) or eccentric (downhill) |
|
| Measure | Description | Time Frame |
|---|---|---|
| level of corticospinal excitability | through study completion, an average of 4 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Dijon Bourgogne | Dijon | 21079 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39674536 | Derived | Dupont W, Papaxanthis C, Lurquin L, Lebon F, Madden-Lombardi C. Negated actions are simulated within the primary motor cortex. Neuroscience. 2025 Jan 26;565:468-478. doi: 10.1016/j.neuroscience.2024.12.018. Epub 2024 Dec 12. | |
| 37944123 | Derived | Dupont W, Papaxanthis C, Lebon F, Madden-Lombardi C. Mental Simulations and Action Language Are Impaired in Individuals with Aphantasia. J Cogn Neurosci. 2024 Feb 1;36(2):261-271. doi: 10.1162/jocn_a_02084. |
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| ID | Term |
|---|---|
| D064797 | Physical Conditioning, Human |
| D004558 | Electric Stimulation |
| ID | Term |
|---|---|
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
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this study is interventional because of it acts on the physical and respiratory capacities of patients
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| mental training | Other | The task to imagine for the training group will be an abduction of the thumb |
|
| electrical stimulation | Other | electrical stimulation of the muscles |
|
| D055687 |
| Musculoskeletal and Neural Physiological Phenomena |
| D010812 | Physical Stimulation |
| D008919 | Investigative Techniques |