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| Name | Class |
|---|---|
| Charles University, Czech Republic | OTHER |
| 3rd Department of Internal Medicine - Cardiology | UNKNOWN |
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Acute efficacy of point-by-point radiofrequency ablation for pulmonary vein isolation in patients with atrial fibrillation are comparable independantly of the ablation strategy (continous versus discontinuous ablation) under the same condition of power delivery.
The number of pulmonary vein isolation (PVI) therapy for atrial fibrillation (AF) is increasing. Durable PVI is cornerstone for long-term freedom of AF. In one previous study continuous ablation was suggested to be more efficient in durable PVI. However, this hypothesis has not been proven in randomized fashion.
The current study is to confirm whether continuous versus discontinuous design of encircling lesions are comparable under the same conditions of power delivery.
The study design is a two-centre prospective randomized trial to compare the acute efficacy by using the above described approaches.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Discontinuous ablation | Experimental | perform discontinuous ablation of ipsilateral pulmunary veins. |
|
| Continuous ablation | Active Comparator | perform continuous ablation of ipsilateral pulmunary veins. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| catheter ablation | Procedure | catheter ablation for atrial fibrillation treatment |
|
| Measure | Description | Time Frame |
|---|---|---|
| Combined unsuccessful PVI or PV reconnection | Combined unsuccessfuk PVI after completeing the primary lesion set or PV reconnection during the waiting time | 30 min after ablation |
| Measure | Description | Time Frame |
|---|---|---|
| Early pulmunary veins reconnection | Early pulmunary veins reconnection within the first 10 min after PVI | 10 min. |
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Inclusion Criteria:
Exclusion Criteria:
-
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Bashar Aldhoon, MD, PhD | Contact | +420739528025 | baaĺ@ikem.cz |
| Name | Affiliation | Role |
|---|---|---|
| Bashar Aldhoon, MD, PhD | Institute for Clinical and Experimental Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute for Clinical and Experimental Medicine | Recruiting | Prague | Czechia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34988847 | Derived | Aldhoon B, Peichl P, Osmancik P, Konecny P, Kautzner J, Wichterle D. Acute efficacy of contiguous versus temporally discontiguous point-by-point radiofrequency pulmonary vein isolation in patients with paroxysmal atrial fibrillation: a randomized study. J Interv Card Electrophysiol. 2022 Sep;64(3):661-667. doi: 10.1007/s10840-021-01113-9. Epub 2022 Jan 6. |
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D017115 | Catheter Ablation |
| ID | Term |
|---|---|
| D000078703 | Radiofrequency Ablation |
| D000078702 | Radiofrequency Therapy |
| D013812 | Therapeutics |
| D055011 | Ablation Techniques |
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| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D013514 |
| Surgical Procedures, Operative |