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The purpose of this study is to compare the clinical outcomes depending on catheter ablation strategy for persistent atrial fibrillation. After randomization, investigators will conduct circumferential pulmonary vein isolation alone in a group, and additional posterior box isolation and anterior linear ablation in the other group. Investigators will compare clinical recurrence rate, complication rate, and procedure time, etc.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| circumferential pulmonary vein isolation | Active Comparator | circumferential pulmonary vein isolation |
|
| Linear ablation in addiction to pulmonary vein isolation | Experimental | Linear ablation in addiction to pulmonary vein isolation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| circumferential pulmonary vein isolation | Procedure |
| ||
| Linear ablation in addiction to circumferential pulmonary vein isolation |
| Measure | Description | Time Frame |
|---|---|---|
| Recurrence of atrial fibrillation after catheter ablation | 12 month |
| Measure | Description | Time Frame |
|---|---|---|
| procedure time | 1 day | |
| procedure related complication rate | 12 month | |
| rate of hospitalization |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Severance Cardiovascular Hospital, Yonsei University Health System | Recruiting | Seoul | 120-752 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31753429 | Derived | Lee JM, Shim J, Park J, Yu HT, Kim TH, Park JK, Uhm JS, Kim JB, Joung B, Lee MH, Kim YH, Pak HN; POBI-AF Investigators. The Electrical Isolation of the Left Atrial Posterior Wall in Catheter Ablation of Persistent Atrial Fibrillation. JACC Clin Electrophysiol. 2019 Nov;5(11):1253-1261. doi: 10.1016/j.jacep.2019.08.021. Epub 2019 Oct 30. |
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| Procedure |
|
| 12 month |
| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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