Preoperative Hypnosis Versus Premedication in Gynecological Surgery

Efficacity of Hypnosis Versus Premedication for the Management of Perioperative Anxiety in Gynecological Surgery

The aim of this study is to evaluate the efficacy of an hypnosis session, performed on the eve of a laparoscopic gynecological surgery, on the level of immediate preoperative anxiety measured by State-Trait Anxiety Index (STAI-Y) self-administered questionnaire compared to premedication by alprazolam®.

Inclusion Criteria:

• Patient's age: over 18 years
• Patient care and follow-up at the regional maternity center of Nancy (CHRU of Nancy)
• Female patient for whom gynecological laparoscopic surgery is programmed and lasting longer than 1 hour (ovarian cyst, laparoscopy infertility, laparoscopic promontofixation, noncarcinogenic assisted laparoscopy hysterectomy, endometriosis, diagnostic laparoscopy, pyosalpinx, hydrosalpinx)
• Patient with Physical status score (ASA) score between 1 and 3
• With standardized anesthesia protocol
• Patient affiliated to a Social Security
• Patient has received complete information about the organization of the research and has signed her informed consent

Exclusion Criteria:

• Pretreatment by benzodiazepines
• Known hypersensitivity to Alprazolam® (including undocumented)
• Prohibition conditions to Alprazolam®: Severe respiratory insufficiency, Sleep apnea syndrome, Myasthenia, Severe acute or chronic hepatic impairment
• Ongoing major depressive episode
• Chronic use (> 1 month) of benzodiazepines or morphine or analgesics of level 2
• Participation in a therapeutic trial 6 months before inclusion in this trial
• Patient referred to in Articles L. 1121-5 to L. 1121-8 and L1122-2 of the Public Health Code