Reassessment of Premedication in Surgery

Assessment of Two Modes of Premedication in Surgery - PREMED Study

The purpose of this study is to test the level of anxiety in patients, the day before surgery (late afternoon) and immediately prior to surgery in 3 parallel groups of patients.

• one receiving placebo before going to sleep (before sleep), the day prior surgery and placebo when awakening (awakening), the day of surgery
• one receiving zopiclone (7.5 mg) before sleep and placebo at awakening
• one receiving placebo before sleep and alprazolam (0.5 mg)at awakening

double blind, randomized controlled study

Eligibility:

• 18 to 65 years old
• elective surgery
• in-hospital preoperative night

Outcome measures:

• anxiety scales
• demographic data

Inclusion Criteria:

• age 18-65 years old
• elective surgery
• in-hospital night before surgery

Exclusion Criteria:

• myasthenia gravis
• chronic intake of psychotropic drugs
• opiates intake
• severe obstructive sleep apnea
• intracranial hypertension
• morbid obesity
• myasthenia gravis
• acute severe medical disorder
• non health insurance coverage
• protected patients by law
• pregnancy
• non French speaking