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Decision of the funder: Almond Board of California
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| Name | Class |
|---|---|
| Almond Board of California | OTHER |
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The overall goal is to assess the health benefits of almond consumption on gut microbiome patterns and their association with circulating disease risk biomarkers, as well as the processes that control those pathways. Health benefits will be assessed relative to a omelette control.
Men and women with elevated waist circumference aged between 18-75 yrs will be recruited from the Winnipeg (Manitoba, Canada) area to participate in a two arm crossover, randomized study; each treatment period will be 4 weeks in length, with a 4 week washout period separating each treatment. Participants will be randomized to consume either i) almonds, or ii) omelettes at 15% of energy. Each of the treatment products will contain equal levels of calories.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Almonds | Experimental |
| |
| Omelette | Active Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Almonds | Other | Almonds will be provided as 15% energy |
| |
| Omelette |
| Measure | Description | Time Frame |
|---|---|---|
| Gastrointestinal microbiome | Bacterial community alpha-diversity measured using richness and diversity indices including Chao1, Shannon, Inverse Simpson. Bacterial community beta-diversity measured using weighted and unweighted UniFrac distances. The most abundant Operational Taxonomic Units (OTUs) within the bacterial community identified based on the relative abundances of the OTUs within the community. Bacterial community composition at the phylum and genus levels described based on the relative abundances of each taxa within the community. Bacterial community functional capacity measured based on the relative abundances of collected predicted functions of the community members. Ecological relationships between members of bacterial community assessed using correlation network modelling to identify keystone and foundation members of the bacterial community that have the highest number of positive (supportive) or negative (suppressive) connections (>15) with other members of community. | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Blood total cholesterol | 4 weeks | |
| Blood low-density lipoprotein cholesterol | 4 weeks | |
| Blood high-density lipoprotein cholesterol |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rotimi Aluko, PhD | University of Manitoba | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba | Winnipeg | Manitoba | R3T 6C5 | Canada |
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| ID | Term |
|---|---|
| C000625003 | Rab1 protein, Drosophila |
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| Other |
Omelettes will be provided as 15% energy |
|
| 4 weeks |
| Blood triglycerides | 4 weeks |
| Interferon gamma | 4 weeks |
| Interleukin 1 beta | 4 weeks |
| Interleukin 6 | 4 weeks |
| Tumor necrosis factor alpha | 4 weeks |
| Serum amyloid A | 4 weeks |
| C-reactive protein | 4 weeks |
| Vascular cell adhesion molecule 1 | 4 weeks |
| Intercellular adhesion molecule 1 | 4 weeks |
| 7α-hydroxy-4-cholesten-3-one | 4 weeks |
| Fecal short chain fatty acids | 4 weeks |
| Fatty acid synthesis rate | 4 weeks |
| Cholesterol synthesis rate | 4 weeks |
| Cholesterol absorption rate | 4 weeks |
| Body mass index | Weight and height will be combined to report BMI in kg/m^2 | 4 weeks |
| Waist circumference | 4 weeks |
| Hip circumference | 4 weeks |
| Blood pressure | 4 weeks |