FCH PET/MRI Parathyroid Localization

18F-Fluorocholine PET/MRI for the Localization of Parathyroid Adenomas

A prospective trial comparing the accuracy of [F-18]-FCH PET/MRI to US and 99mTc-MIBI SPECT/CT for pre-operative parathyroid localization in patients with primary hyperparathyroidism

Inclusion Criteria:

• Age ≥ 18 years
• Biochemically proven primary hyperparathyroidism
• Indication for parathyroidectomy as per institutional guidelines

Exclusion Criteria:

• Contraindication for MRI as per current institutional guidelines.
• Contraindication for Gadolinium injection as per current institutional guidelines.
• Renal failure
• Inability to lie supine for at least 45 minutes.
• Any participant who is pregnant or breastfeeding.
• Participants receiving erythropoietin (i.e. for hemochromatosis; might lead to false negative results due to stimulation of bone marrow metabolism)
• Familial HPT syndromes
• Participant currently being treated with any cytotoxic chemotherapy