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A comparative prospective study to evaluate different imaging modalities (pet-ct and pet-mr) prior to surgery in parathyroid tumor patients.
Patients with Hyperthyroidism and surgery indication will be recruited and directed to imagine exams. in addition to the conservative 99mTc-MIBI (methoxyisobutylisonitrile) and US, patients will also undergo 18FCH (¹⁸F-choline) PET/MRI for detecting adenomas and their location. imaging experts will decode the imaging exams. sensitivity and specificity of the exams will be examined.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Group | Other | primary hyperthyroidism patients that will be refered to the routine exams (PET-CT) |
|
| Study group | Other | primary hyperthyroidism patients that will be refered to the routine exams (PET-CT) and in addition will also undergo the PET-MR |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PET-MR | Device | Patients with Hyperthyroidism and surgery indication will be recruited and directed to imagine exams. In addition to the conservative 99mTc-MIBI and US, patients will also undergo 18FCH PET/MRI for detecting adenomas and their location. |
| Measure | Description | Time Frame |
|---|---|---|
| Adenomas size and location | Location of adenomas by a report analyzing the pathological examination (PET-CT/PET-MR output). | 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Parathyroid hormone levels | approval late addition level of parathyroid hormone (PTH) before and during the course of the operation after the conclusion of adenomas (Hormone levels). | 24 months |
| Chronic disease duration |
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Inclusion Criteria:
Patients who meet the criteria accepted in the World Health Organization (WHO) analysis:
or at least one of the following criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Avi Hefetz, MD | Contact | 972528661361 | avihef1@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Avi hefetz, MD | Assuta Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Assuta Medical Center | Tel Aviv | Israel | Israel |
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| ID | Term |
|---|---|
| D006980 | Hyperthyroidism |
| ID | Term |
|---|---|
| D013959 | Thyroid Diseases |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D000072078 | Positron Emission Tomography Computed Tomography |
| ID | Term |
|---|---|
| D049268 | Positron-Emission Tomography |
| D014055 | Tomography, Emission-Computed |
| D007090 | Image Interpretation, Computer-Assisted |
| D003952 | Diagnostic Imaging |
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| PET-CT | Device | Patients with Hyperthyroidism and surgery indication will be recruited and directed to imagine exams. In addition to the conservative 99mTc-MIBI and US, patients will also undergo PET-CT for detecting adenomas and their location. |
|
time from chronic diseases indication and duration of symptoms measured in months (from the medical records).
| 24 months |
| Disease related medication consumption | Disease related medication consumption measured in miligram (mg) for each medication (from medical records). | 24 months |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D014057 | Tomography, X-Ray Computed |
| D064847 | Multimodal Imaging |
| D011856 | Radiographic Image Enhancement |
| D007089 | Image Enhancement |
| D010781 | Photography |
| D011859 | Radiography |
| D014056 | Tomography, X-Ray |
| D011877 | Radionuclide Imaging |
| D014054 | Tomography |
| D003947 | Diagnostic Techniques, Radioisotope |