Localization of Parathyroid Adenoma by Fluorocholine PET/MRI (Positron Emission Tomography -MRI)

Localization of Parathyroid Adenoma by Fluorocholine Positron Emission Tomography/MRI (PET/MRI): A Prospective Pilot Study

A comparative prospective study to evaluate different imaging modalities (pet-ct and pet-mr) prior to surgery in parathyroid tumor patients.

Patients with Hyperthyroidism and surgery indication will be recruited and directed to imagine exams. in addition to the conservative 99mTc-MIBI (methoxyisobutylisonitrile) and US, patients will also undergo 18FCH (¹⁸F-choline) PET/MRI for detecting adenomas and their location. imaging experts will decode the imaging exams. sensitivity and specificity of the exams will be examined.

Inclusion Criteria:

Patients who meet the criteria accepted in the World Health Organization (WHO) analysis:

• Symptomatic patients (constipation, depression, peptic ulcer, pathologic fractures, chronic fatigue, pain from a urinary tract stones etc..)

or at least one of the following criteria:

• Blood calcium levels above 1 more than normal
• Creatinine clearance decreased in 30% from age expected
• Urine Creatinine above 400 mg in 24 hours

Exclusion Criteria:

• Patients with hyperthyroidism secondary and tertiary (secondary to kidney disease)
• Patients who are not eligible to sign an informed consent
• Pregnant women
• Patients with sensitivity (allergy) technetium or 18FCH