Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study will be to examine the acute effect of commercially available energy products on endothelial function, arterial stiffness and thrombosis in healthy young males.
The use of energy products has significantly increased in the last few years and is especially high among young men. The present study will compare the acute effect of a commercially available energy drink, energy gum, coffee and control beverage on endothelial function, arterial stiffness and circulating markers of thrombosis, inflammation and oxidative stress.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Energy drink and placebo gum | Active Comparator | Commercially-available energy drink (16oz) + 2 pieces of placebo gum |
|
| Caffeinated drink and placebo gum | Active Comparator | Commercially-available caffeinated drink (16oz) + 2 pieces of placebo gum |
|
| Control drink and energy gum | Active Comparator | Control drink (16oz) + 2 pieces of energy gum |
|
| Control drink and placebo gum | Placebo Comparator | Control drink (16oz) + 2 pieces of placebo gum |
|
| Energy drink and total sleep deprivation | Active Comparator | Commercially-available energy drink (16oz) + 2 pieces of placebo gum following total sleep deprivation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| energy drink | Other | 16 oz cold commercially-available energy drink |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in endothelial function | Brachial artery flow-mediated dilation | Before and 1 and 2 hrs following consumption of drink and gum |
| Measure | Description | Time Frame |
|---|---|---|
| Change in arterial stiffness | Carotid to femoral pulse wave velocity | Before and 1 and 2 hrs following consumption of drink and gum |
| Change in wave reflection | Augmentation index |
Not provided
Inclusion Criteria:
Exclusion criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Demetra Christou, PhD | University of Florida | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Florida | Gainesville | Florida | 32611 | United States |
Not provided
| ID | Term |
|---|---|
| D061215 | Energy Drinks |
| ID | Term |
|---|---|
| D001628 | Beverages |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| caffeinated drink | Other | 16oz cold commercially-available caffeinated drink |
|
| Energy gum | Other | 2 pieces of commercially-available energy gum |
|
| placebo gum | Other | 2 pieces of commercially-available placebo gum |
|
| Control drink | Other | 16oz cold control drink |
|
| Total sleep deprivation | Other | 24-hour total sleep deprivation prior to consumption of energy drink and placebo gum |
|
| Before and 1 and 2 hrs following consumption of drink and gum |
| Change in peripheral and central blood pressures | Brachial and aortic blood pressures | Before and 1 and 2 hrs following consumption of drink and gum |
| Change in thrombosis and platelet function | Thromboelastograph and platelet aggregation tests | Before and 1 and 2 hrs following consumption of drink and gum |
| Change in circulating factors related to vascular function | Circulating levels of Trimethylamine N-oxide (TMAO) and markers of oxidative stress and inflammation | Before and 1 and 2 hrs following consumption of drink and gum |
| Change in heart rhythm | Electrocardiogram | Before and 1 and 2 hrs following consumption of drink and gum |