Low Fat Diet for Fatigue in MS

A Randomized, Controlled Trial of Low-fat Diet for Fatigue in Multiple Sclerosis

A randomized, controlled pilot trial of a dietary intervention vs. wait-list control in patients with MS and fatigue for management of their fatigue. The hypothesis of this study is that participants following the low-fat study diet will demonstrate a significant reduction in fatigue after four months compared to wait list controls.

For participants with MS:

Inclusion Criteria:

• Age 18-70
• Diagnosis of MS by 2010 McDonald Criteria
• EDSS ≤ 7.5
• Experiencing moderate to severe fatigue (MFIS ≥ 38)

Exclusion Criteria:

• Current cardiopulmonary disease requiring treatment
• Diabetes
• Pregnancy or breast-feeding
• MS exacerbation within 30 days of screening visit
• IV steroids within 30 days of screening visit
• Dietary fat content of <30% as assessed by food frequency questionnaire (FFQ) at screening visit
• Fish oil or flax seed oil supplementation within 30 days of screening visit