The aim of this clinical trial is to study the effect of an intravenous infusion of lidocaïne in a multimodal analgesic protocol on the architecture sleep during the first postoperative night.

To study the effect of lidocaïne, we plan to include 40 patients, randomized in 2 groups, undergoing open prostate surgery in this randomized placebo-controlled trial.

Before anesthesia induction, these patients receive an intravenous lidocaine infusion (bolus 1,5 mg.kg-1 followed by a continuous infusion of 2mg.kg-1.h during 24 hours) or an equal volume of placebo. Then the anesthesia is induced with propofol, sufentanil et rocuronium. The postoperative analgesia is provided by paracetamol, tramadol and patient-controlled analgesia (PCA) with morphine or oral oxycodone. A polysomnography is registred on the preoperative night and on the first postoperative night.

Inclusion Criteria:

• Radical prostatectomy

Exclusion Criteria:

• BMI > 30
• Neurologic/psychiatric diseases or therapeutics, seizyres
• Cardiac disease, second or third degree atrioventricular block
• Obstructive sleep apnea syndrome
• History of liver or renal insufficiency
• and any contraindication to the anesthetic protocol of the study.