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Less patients than expected for inclusion, therefore patient recruitment is to low
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| Name | Class |
|---|---|
| International Anesthesia Research Society (IARS) | OTHER |
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The purpose of this study is to comparing effects of intravenously (IV) administered lidocaine to effects of epidurally (ED) administered lidocaine in patients undergoing elective colorectal surgery
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Lidocaine i.v |
|
| 2 | Active Comparator | intraoperatively lidocaine epidural postoperatively lidocaine i.v. |
|
| 3 | Active Comparator | intraoperatively lidocaine i.v. postoperatively lidocaine epidural |
|
| 4 | Active Comparator | lidocaine epidural |
|
| 5 | Placebo Comparator | placebo i.v. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| lidocaine | Drug | administration of lidocaine intravenously or epidural or administration of placebo |
|
| Measure | Description | Time Frame |
|---|---|---|
| length of postoperative hospital stay | end of hospital stay |
| Measure | Description | Time Frame |
|---|---|---|
| Hyperalgesia perioperative | postoperative day 2, 4, 8, end of hospital stay and follow-up | |
| Cytokine levels perioperative | before surgery and 4 hours, 2 and 4 days after surgery | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| K Hahnenkamp, MD | Department of Anesthesiology and Intensive Care, University Hospital Muenster | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Muenster | Münster | D-48129 | Germany | |||
| St. Franziskushospital Muenster |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16952918 | Background | Kuo CP, Jao SW, Chen KM, Wong CS, Yeh CC, Sheen MJ, Wu CT. Comparison of the effects of thoracic epidural analgesia and i.v. infusion with lidocaine on cytokine response, postoperative pain and bowel function in patients undergoing colonic surgery. Br J Anaesth. 2006 Nov;97(5):640-6. doi: 10.1093/bja/ael217. Epub 2006 Sep 4. | |
| 71604 |
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D008012 | Lidocaine |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 |
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| NaCl 0,9% | Drug | Administration of placebo i.v. |
|
| Bowel motility perioperative |
| days after surgery |
| Length of PACU stay | end of PACU stay |
| Cognitive function perioperatively | before surgery, one and four days after surgery, at end of hospital stay and follow-up |
| Incidence of wound healing disturbances | within 4 weeks after surgery |
| Postoperative Analgesia | until end of hospital stay |
| Münster |
| D-48145 |
| Germany |
| St. Marienhospital | Vechta | D-49377 | Germany |
| Cooke ED, Bowcock SA, Lloyd MJ, Pilcher MF. Intravenous lignocaine in prevention of deep venous thrombosis after elective hip surgery. Lancet. 1977 Oct 15;2(8042):797-9. doi: 10.1016/s0140-6736(77)90727-9. |
| Aniline Compounds |
| D000588 | Amines |