Analgesic Efficacy of Intravenous Lidocaine and/or Ketamine

Analgesic Efficacy of Intravenous Perfusion of Lidocaine, Ketamine or a Combination After Laparotomy in a Placebo-controlled, Randomized, Double-blind Prospective Study

The aim of the present study is to evaluate the analgesic benefit of intravenous lidocaine and ketamine in the perioperative period of abdominal surgery.

Optimal postoperative pain management facilitates rehabilitation immediately after abdominal surgery. Multiple studies have demonstrated that successful postoperative analgesia also reduces perioperative complications and improves patient comfort, thereby providing many benefits for the patient. In acute postoperative pain management intravenous lidocaine and/or ketamine have been advocated because of their morphine-sparing effect.

Inclusion Criteria:

• abdominal surgery by laparotomy

Exclusion Criteria:

• laparoscopy
• history of chronic pain
• opioid self-administration
• psychiatric disorders
• difficulties with communication
• renal or hepatic dysfunction
• ASA physical status > 3