Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Shaoxing Second Hospital | OTHER |
| Haining People' s Hospital | UNKNOWN |
| Haiyan People's Hospital | OTHER |
| Huzhou No.1 People' s Hospital |
Not provided
Not provided
Not provided
Not provided
Not provided
A cluster randomised controlled trial will be conducted, using hospital as randomisation unit. Hospitals in Zhejiang Province, China, will be randomised into two arms (1:1): an intervention arm and a control arm. Hospitals in the intervention arm will receive a multi-components intervention based on the Behaviour Change Wheel model, whereas hospitals in the control arm will receive no intervention and maintain existing care. The randomisation will be conducted after one-year baseline data collection. The following baseline data will be used for randomisation match: hospital classification, beds in stroke centre, thrombolysis patient number, and percentage of patients receiving thrombolysis within 60 minutes of stroke onset. Hospitals with no stroke centre or with <20 cases received thrombolysis per year will be excluded from the study. The primary outcome will be difference between intervention arm and control arm in the percentage of patients receiving thrombolysis within 60 minutes of stroke onset on the follow-up stage (post-intervention).
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| an intervention arm | Experimental | Hospitals in the intervention arm will receive a multi-components intervention based on the Behaviour Change Wheel model |
|
| a control arm | No Intervention | hospitals in the control arm will receive no intervention and maintain existing care |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Behaviour Change Wheel model guided intervention | Behavioral | Interventions are developed on a psychological model, the Behaviour Change Wheel (BCW) .The fundamental of BCW consists of three essential elements: capability, motivation, and opportunity. Improving individual's capability, providing motivation, and increasing opportunities are goals of behaviour change intervention. To achieve the goals, 9 intervention components have been proposed in the BCW framework, and 6 components will be used in current study. |
| Measure | Description | Time Frame |
|---|---|---|
| Difference in the percentage of patients who Door-to-Needle Time≤60min | Difference between intervention arm and control arm in the percentage of patients receiving thrombolysis within 60 minutes of stroke onset on the follow-up stage | Up to 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Door-to-needle time | The time between hospital arrival and the initiation of IVT | Up to 24 hours |
| Onset-to-needle time | The time between the symptom onset and the initiation of IVT |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The second affiliated hospital of Zhejiang University | Hangzhou | Zhejiang | 310000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37565934 | Derived | Lynch EA, Bulto LN, Cheng H, Craig L, Luker JA, Bagot KL, Thayabaranathan T, Janssen H, McInnes E, Middleton S, Cadilhac DA. Interventions for the uptake of evidence-based recommendations in acute stroke settings. Cochrane Database Syst Rev. 2023 Aug 11;8(8):CD012520. doi: 10.1002/14651858.CD012520.pub2. | |
| 35788767 | Derived |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
Not provided
Not provided
| UNKNOWN |
| Jiashan No.1 People' s Hospital | UNKNOWN |
| Ningbo Medical Center Lihuili Hospital | OTHER_GOV |
| Tongxiang No.1 People' s Hospital | UNKNOWN |
| First Affiliated Hospital of Wenzhou Medical University | OTHER |
| Yiwu Central Hospital | OTHER |
| Yongkang No.1 People' s Hospital | UNKNOWN |
| Yuyao People's Hospital | OTHER |
| Deqing People' s Hospital | UNKNOWN |
| Dongyang People's Hospital | OTHER |
| Jinhua People' s Hospital | UNKNOWN |
| Lishui People' s Hospital | UNKNOWN |
| Lin' an People' s Hospital | UNKNOWN |
| Longquan People' s Hospital | UNKNOWN |
| Qingtian People' s Hospital | UNKNOWN |
| Shaoxing Central Hospital | OTHER |
| Wenzhou Central Hospital | OTHER |
| Xiangshan No.1 People' s Hospital | UNKNOWN |
| The Central Hospital of Lishui City | OTHER |
Not provided
Not provided
Not provided
Not provided
|
| Up to 24 hours |
| modified Rankin Scale score at discharge | modified Rankin Scale score at discharge, on which scores range from 0 (no neurologic deficit) to 6 (death) | Up to 3 month |
| Symptomatic intracranial hemorrhage | Intracranial hemorrhage at 24 hours associated with an increase of ≥4 points of NIHSS score from baseline, according to European Cooperative Acute Stroke Study (ECASS) II trial | At 24 hours |
| Favorable neurological outcomes | Score of 0 to 1 on the modified Rankin Scale, on which scores range from 0 (no neurologic deficit) to 6 (death) | At 90 days |
| Death | Death at discharge | Up to 3 month |
| Zhong W, Lin L, Gong X, Chen Z, Chen Y, Yan S, Zhou Y, Zhang X, Hu H, Tong L, Cheng C, Gu Q, Chen Y, Yu X, Huang Y, Yuan C, Lou M; MISSION investigators. Evaluation of a multicomponent intervention to shorten thrombolytic door-to-needle time in stroke patients in China (MISSION): A cluster-randomized controlled trial. PLoS Med. 2022 Jul 5;19(7):e1004034. doi: 10.1371/journal.pmed.1004034. eCollection 2022 Jul. |
| 34423654 | Derived | Wang J, Gong X, Zhong W, Zhou Y, Lou M. Novel Prehospital Triage Scale for Detecting Large Vessel Occlusion and Its Cause. J Am Heart Assoc. 2021 Sep 7;10(17):e021201. doi: 10.1161/JAHA.121.021201. Epub 2021 Aug 21. |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |