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In case of CDH, the incomplete development of a part of the diaphragm allows abdominal viscera to herniate into thorax cavity during fetal development and impaired lung and heart development.
After birth, CDH patients who survived thanks to an active reanimation management undergo diaphragmatic repair. In case of large defect, a patch is needed to complete diaphragmatic closure. Thanks to primary cell culture from foreskin, peritoneal epithelium or cremaster dedicated to incineration investigators want to analyse biological integration of actually used prothesis and others innovations.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Foreskin resection | Procedure | During the pediatric surgery consultation, the doctor will decide between Foreskin resection, orchidopexie or inguinal hernia repair. |
|
| Measure | Description | Time Frame |
|---|---|---|
| cell colonization | Study cell colonization | samples are processed immediately after sampling |
| quality of the extracellular matrix | Quality of the extracellular matrix produced in vitro in contact with the currently used implant materials compared to biomaterials under development | samples are processed immediately after sampling |
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Inclusion Criteria:
Exclusion Criteria:
- parents don't agree to the use of its operating waste for research purposes
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Children that benefits of a foreskin resection, inguinal hernia repair or orchidopexy
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| Name | Affiliation | Role |
|---|---|---|
| Isabelle TALON, MD | Les Hôpitaux Universitaires de Strasbourg | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Les Hôpitaux Universitaires de Strasbourg | Strasbourg | 67098 | France |
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