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Inability to commence study after COVID-19 research curtailment and loss of research personnel
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Tibiofemoral osteoarthritis (TFOA) is highly prevalent in older adults, and often causes symptoms and functional limitations. Physical activity is widely advocated in people with TFOA, and running is an easy and accessible activity that provides many benefits on general health. However, running induces high knee loads, which could potentially contribute to symptoms of runners with TFOA. Previous studies have suggested that running gait modifications can help in decreasing symptoms and knee loading in runners with knee conditions. Yet, no study has been conducted in runners with TFOA. This intervention study will investigate the effects of a 4-week running gait retraining program on symptoms and running biomechanics in runners with TFOA. We hypothesize that running modifications will decrease symptoms, improve function and reduce knee loading.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Gait retraining | Experimental | Runners will be taught how to modify their running gait through multiple laboratory sessions and in-field training. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Gait retraining | Behavioral | Over a 4-week period, runners will be asked to increase their step rate to reduce knee loading during running. Specifically, they will have to increase their preferred step rate by 10% during weekly laboratory running sessions as well as during habitual running training. In the laboratory, runners will be provided with live visual/auditory biofeedback on step rate and asked to target a specific value representing 110% or preferred step rate. During their individual running sessions, runners will be wearing a GPS-enabled watch that will provide feedback on live step rate, and they will be asked to maintain the same value as in the laboratory. |
| Measure | Description | Time Frame |
|---|---|---|
| Knee Osteoarthritis Outcome Score (KOOS) change | Validated questionnaire on symptoms and functional limitations related to knee osteoarthritis. The score is expressed in percentage (0-100), with 0 representing extreme knee problems and 100 representing no knee problems. | Baseline, 2 weeks, 4 weeks, 2 months, 3 months, 4 months |
| Peak knee adduction moment impulse change | Validated surrogate measure of knee joint loading during movement. Expressed as Nm/kg*sec | Baseline, 4 weeks, 4 months |
| Measure | Description | Time Frame |
|---|---|---|
| Numerical pain rating scale for pain during running change | Validated scale ranging from 0 (no pain) to 10 (worst imaginable pain), in which participants rate their worst level of pain during running over the previous week. | Baseline, 2 weeks, 4 weeks, 2 months, 3 months, 4 months |
| Step rate change |
| Measure | Description | Time Frame |
|---|---|---|
| Compliance with gait retraining change | Compliance with instructions on step rate will be measured through data collected with the provided watch and a logbook. We will also monitor weekly running distance during the course of the study. | During Week 1, 2, 3 and 4 of the retraining program |
| Numeric pain rating scale for usual pain change |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Michael A Hunt, PT, PhD | University of British Columbia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Robert H.N. Ho Research Centre | Vancouver | British Columbia | V5Z 1M9 | Canada |
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| ID | Term |
|---|---|
| D020370 | Osteoarthritis, Knee |
| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
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Single Group cohort study
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Data will be analyzed by an assessor blinded to date of data collection for each testing session. Following data collection, a researcher not involved with data collection or analysis will re-code data timepoints to ensure that the assessor is unaware of the timepoint each datapoint was obtained.
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|
Number of steps taken during one minute of running. |
| Baseline, 4 weeks, 4 months |
| Peak knee flexion moment impulse change | Validated surrogate measure of knee joint loading during running. Expressed as Nm/kg*sec | Baseline, 4 weeks, 4 months |
Validated scale ranging from 0 (no pain) to 10 (worst imaginable pain), in which participants rate their level of pain during their usual daily activities over the previous week. |
| Baseline, 2 weeks, 4 weeks, 2 months, 3 months, 4 months |
| Numeric pain rating scale for worst pain change | Validated scale ranging from 0 (no pain) to 10 (worst imaginable pain), in which participants rate their worst level of pain over the previous week. | Baseline, 2 weeks, 4 weeks, 2 months, 3 months, 4 months |
| D012216 |
| Rheumatic Diseases |