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Knee osteoarthritis (OA) is a debilitating disease affecting millions worldwide. Exercise is a core treatment for knee OA, and is advocated by all clinical guidelines. Running is a common exercise that is accessible and evokes a number of positive physical and psychological benefits. However, the appropriateness of recreational running in the presence of knee OA is unclear.
A growing literature base appears to suggest that running may not be deleterious to the health - especially at the knee joint - of people with knee OA. Our recent research has focused on examining a number of health outcomes relevant to knee OA in older individuals with knee OA, but has been limited to experienced runners. This study will address that limitation by focusing on how novice (new) runners respond to a new running program.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy control | Active Comparator | Pain-free Individuals without radiographic evidence of knee osteoarthritis who will receive the running program intervention |
|
| Knee osteoarthritis group | Active Comparator | Individuals with knee pain and radiographic evidence of knee osteoarthritis who will receive the running program intervention |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Running volume increase | Behavioral | Participants will receive a 6-month running program focusing on gradual increases in weekly running volume (no more than 5% per week, on average). For the purpose of this study, there will be no specific instructions on 'how' to run; rather, participants will simply be instructed on 'how much' to run. |
| Measure | Description | Time Frame |
|---|---|---|
| T2 relaxation time - medial tibia | Magnetic resonance imaging (MRI) of the knee cartilage will be used to measure the exponential decay/dephasing of transverse magnetization of protons, known as T2 relaxation time (measured in milliseconds). Cartilage will be segmented into a number of regions of interest, with relaxation times calculated separately for each region of interest. | Baseline and 6 months |
| T2 relaxation time - medial femur | Magnetic resonance imaging (MRI) of the knee cartilage will be used to measure the exponential decay/dephasing of transverse magnetization of protons, known as T2 relaxation time (measured in milliseconds). Cartilage will be segmented into a number of regions of interest, with relaxation times calculated separately for each region of interest. | Baseline and 6 months |
| T2 relaxation time - patella | Magnetic resonance imaging (MRI) of the knee cartilage will be used to measure the exponential decay/dephasing of transverse magnetization of protons, known as T2 relaxation time (measured in milliseconds). Cartilage will be segmented into a number of regions of interest, with relaxation times calculated separately for each region of interest. | Baseline and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| T1rho relaxation time - medial tibia | Magnetic resonance imaging (MRI) of the knee cartilage will be used to assess the interaction between water and macromolecules. T1rho relaxation time (measured in milliseconds) measures how fast water protons spin-locked to macromolecules leave this locked state. Cartilage will be segmented into a number of regions of interest, with relaxation times calculated separately for each region of interest. |
| Measure | Description | Time Frame |
|---|---|---|
| Numerical rating scale of pain | 11-point numerical rating scale; 0 = no pain; 10 = worst pain imaginable | Baseline and 6 months |
| Knee joint contact force impulse during running | 3D motion capture technology will be used to measure joint motion trajectories and external forces applied to the lower limb during running. Musculoskeletal modelling techniques will be used to calculate the contact force within the tibiofemoral joint. |
Inclusion criteria (all):
Inclusion criteria (knee osteoarthritis (OA) group):
Inclusion criteria (Control group):
Exclusion Criteria (all):
Additionally, exclusion criteria based on MRI safety:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Natasha Krowchuk, BSc | Contact | 604-822-7948 | natasha.krowchuk@ubc.ca |
| Name | Affiliation | Role |
|---|---|---|
| Michael Hunt, PT, PhD | The University of British Columbia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Motion Analysis and Biofeedback Laboratory, The University of British Columbia | Vancouver | British Columbia | V6T 1Z3 | Canada |
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| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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|
| Baseline and 6 months |
| T1rho relaxation time - medial femur | Magnetic resonance imaging (MRI) of the knee cartilage will be used to assess the interaction between water and macromolecules. T1rho relaxation time (measured in milliseconds) measures how fast water protons spin-locked to macromolecules leave this locked state. Cartilage will be segmented into a number of regions of interest, with relaxation times calculated separately for each region of interest. | Baseline and 6 months |
| T1rho relaxation time - patella | Magnetic resonance imaging (MRI) of the knee cartilage will be used to assess the interaction between water and macromolecules. T1rho relaxation time (measured in milliseconds) measures how fast water protons spin-locked to macromolecules leave this locked state. Cartilage will be segmented into a number of regions of interest, with relaxation times calculated separately for each region of interest. | Baseline and 6 months |
| Knee Injury and Osteoarthritis Outcome Score (KOOS) - pain subscale | There are 9 questions in this subscale, with each question scored on a 5-point Likert scale ranging from "None" to "Extreme". The total sum of this subscale is calculated and divided by the maximum score to generate a score out of 100. Subscale totals range from 0 to 100, with higher scores indicating less pain. | Baseline and 6 months |
| Knee Injury and Osteoarthritis Outcome Score (KOOS) - function in daily living subscale | There are 17 questions in this subscale, with each question scored on a 5-point Likert scale ranging from "None" to "Extreme". The total sum of this subscale is calculated and divided by the maximum score to generate a score out of 100. Subscale totals range from 0 to 100, with higher scores indicating less pain. | Baseline and 6 months |
| Baseline and 6 months |
| D001519 |
| Behavior |